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ProteomicsQuantitative GTPase affinity purification identifies Rho family protein interaction partners
Although Rho GTPases are essential molecular switches involved in many cellular processes, an unbiased experimental comparison of their interaction partners was not yet performed. Here, we develop quantitative GTPase affinity purification (qGAP) to systematically identify interaction partners of six...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-12-23 | PXD004190 | Pride
Interaction proteomics Rho gtpase 
ProteomicsQuantitative interaction proteomics of neurodegenerative disease proteins
Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2015-09-22 | PXD001942 | Pride
Neurodegeneration Qap-ms 
UnknownProgestogens and androgens influence root morphology of angiosperms in a brassinosteroid-independent manner.
Not available
S-EPMC12419790 | biostudies-literature
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
GenomicsSingle-cell DNA methylome sequencing and bioinformatic inference of epigenetic cell state dynamics
Here we describe a method for whole genome bisulfite sequencing in very small cell populations (µWGBS) and in single cells (scWGBS). Our method is optimized for profiling DNA methylation in many samples at low coverage, and we developed a bioinformatic method that uses collections of single-cell met...
ORGANISM(S): Mus musculus 
2015-02-25 | E-GEOD-65196 | biostudies-arrayexpress
TranscriptomicsAffymetrix GeneChip Mouse Gene 1.0 arrays of RNA extracted from gastrocnemius muscle of 4 global Ppp3cb KO mice and 4 corresponding WT littermates, and 4 skeletal muscle-specific Ppp3r1Mlc1fCre KO and 4 corresponding WT littermates.
Global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle but not adipose tissue or liver led to protection from high-fat diet induced obesity and comorbid sequelæ. Ser637 hyperphosphorylation of dynamin-related protein 1 (Drp1) in ...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-71174 | biostudies-arrayexpress
ProteomicsRBPome of primary mouse T helper cells
Post-transcriptional gene regulation by mRNA-binding proteins (RBPs) ensures an important layer to control protein outcome. It includes many fundamental processes, ranging from splicing to transport, decay and translation. Although recent technical developments allow the identification of mRNA-bindi...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-01 | PXD008830 | Pride
Rbp Mrna interactome capture Immune cells 
TranscriptomicsBMP9_BMPR2_PAEC_BOEC
Human pulmonary arterial endothelial cells (PAECs) and blood outgrowth endothelial cells (BOECs) from healthy subjects were stimulated with BMP9, BMP2 or BMP6. and assessed for changes in gene transcription by microarray. Unlike BMP2 and BMP6, which had negligible impacts on gene expression, BMP9 in...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-MTAB-2495 | biostudies-arrayexpress
Transcriptomics450k Analysis of 3 FF HPV+ and 3 FF HPV- HNSCC samples
The methylation analysis of 3 FF HPV+ HNSCC samples and 21 FP HPV- HNSCC samples by Infinium HumanMethylation450 BeadChip Analysis of 6 450k methylation profiles, comprising 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38268 | biostudies-arrayexpress
TranscriptomicsLPS hypersensitivity of gp130 mutant mice is independent of elevated hematopoietic TLR4 signaling
The inflammatory mediator IL6 induced by LPS, which signals via TLR4, has been shown to feedback and augment TLR4 signaling when over-produced in LPS hypersensitive gp130F/F mice. The identity of the LPS/TLR4 responsive inflammatory signaling pathways and gene networks which are modulated by IL6 ar...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29311 | biostudies-arrayexpress
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