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ProteomicsDistinct phases of cellular signaling revealed by time-resolved protein synthesis
The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this level provide opportunities for manipulating cellular states. Here, we deploy a proximity-triggered protein trans-splicing technology to enable the time...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-10-06 | PXD044530 | Pride
Signaling Silac ap-ms Protein engineering Prm Tmt-phosphoproteomics Fusion oncogenes 
ProteomicsQuantitative interaction proteomics of neurodegenerative disease proteins
Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2015-09-22 | PXD001942 | Pride
Neurodegeneration Qap-ms 
ProteomicsNon-competitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in E. coli
The SecYEG translocon constitutes the major protein transport channel in bacteria and transfers an enormous variety of different secretory and inner-membrane proteins. The minimal core of the SecYEG translocon consists of three inner-membrane proteins, SecY, SecE, and SecG, which, together with appr...
ORGANISM(S): Escherichia coli 
2019-11-07 | PXD015985 | Pride
Interaction proteomics Yidc Ppid Protein translocation Secyeg translocon Protein cross-linking Protein-protein interaction Quantitative affinity purification mass spectrometry (qap-ms) 
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