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Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various components of the spliceosome: proteins and a n...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027950 | Pride
UOK257 cell line was derived from a BHD patient. It harbors a germline mutation in FLCN (c.1285dupC) and LOH. UOK257-2 cells were generated from UOK257 cells by introducing wildtype FLCN using retrovirus. FLCN inactivation induces TFE3 transcriptional activity by increasing its nuclear localization....
ORGANISM(S): Homo sapiens 
Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various spliceosomal proteins. We have observed this ph...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027948 | Pride
Exogenous signals from drug-stressed cancer cells promote acquisition of a more aggressive phenotype of neighboring tumor cells. Recently, we examined how cancer cell secretome changes in response to chemotherapy. Moreover, therapy-induced secretomes significantly increased resistance of cancer cell...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027794 | Pride
Tumors easily acquire resistance to individual drugs and drug combinations thereby limiting the treatment effectiveness. Drug-stressed tumor cells secrete components that promote the survival of recipient cells and repopulation of damaged tumors. We have previously found that therapy-induced secreto...
ORGANISM(S): Homo sapiens (Human) 
2018-05-22 | PXD007615 | Pride
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