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TranscriptomicsDifferences in gene expression patterns in mouse embryonic fibroblast Flp-In-3T3 cell lines stably expressing Pax6 or Pax6(5a).
Novel target genes for the two transcription factor isoforms Pax6 and Pax6(5a) were identified by generating mouse embryonic fibroblast cell lines stably expressing either Pax6 or Pax6(5a), and comparing their gene expression pattern with the original mouse embryonic fibroblast cell line. Flp-In-3T3...
ORGANISM(S): Mus musculus 
2012-03-22 | E-GEOD-31402 | biostudies-arrayexpress
GenomicsIdentification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-66961 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat wild type and Pax6 mutant hindbrain and forebrain samples
Pax6 is a transcription factor that is expressed in neuroepithelial cells from the initial stage of brain development. Region specific expression of Pax6 plays pivotal roles in the developing CNS, including brain patterning, neuronal specification, neuronal migration, and axonal projection. Regard...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2272 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of E15.5 mouse Insm1, Neurod1 and Pax6 knockouts vs Insm1GFP.Cre/+ controls
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1GFP.Cre/+ controls and Insm1 (Insm1GFP.Cre/GFP.Cre), Neurod1 (Insm1GFP.Cre/+; Neurod1LacZ/LacZ), or Pax6 (Insm1GFP.Cre/+; Pax6fl/fl) knockout FACS sorted pancreatic endocrine cells at E15.5. Comparison of Insm1GFP.Cre+/...
ORGANISM(S): Mus musculus 
2021-08-23 | E-MTAB-10262 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice
RNA-Seq to investigate significant transcriptional differences underlying the defective glucose-stimulated insulin secretion of Pax6 knockout mice in comparison to floxed littermate controls.
ORGANISM(S): Mus musculus 
2017-04-26 | E-MTAB-5708 | biostudies-arrayexpress
TranscriptomicsPax6 mutant neocortex vs. wild type
Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32271 | biostudies-arrayexpress
TranscriptomicsFunctional dissection of the Paired domain of Pax6 – distinct roles of subdomains in neurogenesis and proliferation
The transcription factor Pax6 acts as a key developmental regulator in various organs. In the developing brain Pax6 regulates patterning, neurogenesis and proliferation, but how these diverse effects are mediated at the molecular level is not well understood. As Pax6 regulates forebrain development ...
ORGANISM(S): Mus musculus 
2013-03-19 | E-GEOD-35260 | biostudies-arrayexpress
TranscriptomicsE12.5 Murine lateral cortical progenitor cells: Pax6sey/sey vs. Pax6+/+
The mechanisms by which the early spatiotemporal expression patterns of transcription factors such as Pax6 regulate the region-specific proliferation rates of neural progenitors are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogen...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-38703 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis in Cornea epithelial cells (CECs), skin epithelial cells (SECs), LSCs after knocking down PAX6 (3-D shPAX6 LSCs) and SESCs transduced with PAX6(3-D PAX6+ SESCs) upon 3-D differentiation
Purpose: We find that Wnt7a-PAX6 axis determine corneal epithelial cell fate. To obtain global evidence for successful cell fate conversion, we performed gene expression profiling by RNA-seq on CECs, SECs, and LSCs after knocking down PAX6 and on SESCs transduced with PAX6 upon 3-D differentiation. ...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-54322 | biostudies-arrayexpress
ProteomicsComparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion
Our team is working on aniridia, an autosomal dominant condition and has used a mouse model. The cornea, the eye’s first avascular and transparent optical surface, is covered by a stratified epithelium that constantly renews itself; any disruption compromises transparency and threatens vision. The t...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD070553 | Pride
Tear proteomics Wound healing Pax6 Aniridia 
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