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TranscriptomicsModeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data
Background. Most colorectal cancers (CRC) arise in a progression through adenoma to carcinoma phenotypes as a consequence of altered genetic information. Clinical progression of CRC may occur in parallel with distinctive signaling alterations. We designed multidirectional analyses integrating microa...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-20916 | biostudies-arrayexpress
ProteomicsHuman bladder cancer and colon cancer quatitative MS/MS
We analyzed a set of 40 independently collected tumor tissue/control samples using a label-free quantitation single pass LC-MS/MS approach. In this set, 10 samples originated from a colon tumor (i.e. AC) and 10 from control non-malignant tissue samples (NCA), as well as 10 from BC samples and 10 fro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082886 | MassIVE
TranscriptomicsPouch transcriptional differences between UC and FAP indicate altered immune response.
A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and selected patients with ulcerative colitis (UC). However, this surgical treatment often associates with a long-term complication, ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-50788 | biostudies-arrayexpress
TranscriptomicsProx1 (Prosper-related homeobox 1) transcription factor depletion effect on CGTH-W-1 cells.
Analysis of CGTH-W-1 follicular thyroid carcinoma cells transcriptome following 48 hrs siRNA-mediated depletion of PROX1. PROX1 is a homeobox transcription factor. PROX1 depletion decreases migratory ability, motility and invasivness and induces profound cytoskeleton changes of CGTH-W-1 cells. ...
ORGANISM(S): Homo sapiens 
2016-07-31 | E-GEOD-80135 | biostudies-arrayexpress
MetabolomicsSerum metabolomic profile in children with type 1 diabetes mellitus: an exploratory targeted metabolomics study of candidate discriminatory features
Background: Type 1 diabetes mellitus (T1DM) is an increasingly common chronic disease caused by autoimmune damage to pancreatic beta cells. Metabolomic profiling may provide insights into metabolic disturbances associated with T1DM and identify candidate biomarkers. Methods: The study included 29 ch...
2026-09-22 | MTBLS15768 | MetaboLights
TranscriptomicsDNA methylation sensitivity at detecting cancer in prostate core biopsies [DNA Methylation Profiles]
The aim of this study was to analyze critically the potential usefulness of selected DNA methylation biomarkers in supporting conventional histological diagnostic tests for PCa. The selection of potential biomarkers was conducted by microarray profiling of DNA methylation on prostate tissues extract...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55598 | biostudies-arrayexpress
TranscriptomicsGene expression sensitivity at detecting cancer in prostate core biopsies [Expression Profiles]
The aim of this study was to analyze critically the potential usefulness of selected RNA biomarkers in supporting conventional histological diagnostic tests for PCa. The selection of potential biomarkers was conducted by microarray profiling of gene expression on prostate tissues extracted from the ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55597 | biostudies-arrayexpress
TranscriptomicsHepatic molecular alterations more than muscle's differentiate obese hyperphagic mice from those prolonged fed with the high-fat diet
Although mitochondrial dysfunctions are implicated in the pathogenesis of obesity, the molecular mechanisms underlying obesity-related metabolic abnormalities are still not well established. To acquire a comprehensive picture of mitochondrial molecular changes within metabolically active tissues, we...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-43691 | biostudies-arrayexpress
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