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TranscriptomicsTranscription profiling by array to assess epidemic methicillin-resistant Staphylococcus aureus 16 phenotypes induced by PBD conjugates
Objectives Pyrrolobenzodiazepine (PBD) dimers, tethered through inert propyldioxy or pentyldioxy linkers, possess potent bactericidal activity against a range of Gram-positive bacteria by virtue of their capacity to cross-link duplex DNA in sequence-selective fashion. Here we attempt to improve the ...
ORGANISM(S): Staphylococcus aureus 
2012-04-17 | E-BUGS-118 | biostudies-arrayexpress
Genomicspbd
pbd
PRJEB78522 | ENA
Genomicspbd
pbd
PRJEB77046 | ENA
ProteomicsIdentification of Plk1-PBD interacting proteins
This project aims to identify Plk1-PBD interactors potentially involved in DNA repair. We performed unbiased proteomic screens in S and G2 phases. HeLa cells were synchronized by double-thymidine block-and-release, and pull-downs were conducted with GST-Plk1 PBD as bait. GST alone and a phospho-bind...
ORGANISM(S): Homo sapiens (Human) 
2026-08-01 | PXD078902 | Pride
Gst pull-down Plk1 Pbd Identification 
TranscriptomicsGene expression profiles of hepatocyte-like cells derived from induced pluripotent stem cells (iPSCs) from donors with the Zellweger spectrum of peroxisome biogenesis disorders (PBD-ZSD) and healthy controls
Skin fibroblasts from individuals with PBD-ZSD, a rare autosomal recessive disorder caused by peroxisome assembly defects, show defects in lipid metabolism that provide the basis for clinical diagnostic tests, but are not among the cell types most affected by disease. To explore phenotypes of more c...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-69066 | biostudies-arrayexpress
UnknownSynthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates.
Not available
S-EPMC7179398 | biostudies-literature
TranscriptomicsGlobal transcriptional changes in the JJN3 myeloma cell line that occur as a result of treatment with 2 pyrrolobenzodiazepine (PBD) monomers
Background: This study characterises a group of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomeric hybrids to investigate the global transcriptional changes that occur as a result of treatment in these cells. It was also of interest to determine whether compounds show a selective inhibitory effect on...
ORGANISM(S): Homo sapiens 
2019-01-22 | GSE125395 | GEO
TranscriptomicsDNA methylation profiles of fibroblasts and induced pluripotent stem cells (iPSCs) from individuals with Zellweger spectrum disorder (ZSD), a class of peroxisome biogenesis disorder, and healthy controls
Zellweger spectrum disorder (PBD-ZSD) is a disease continuum caused by mutations in a subset of PEX genes required for normal peroxisome assembly and function. Their clinical manifestations highlight the importance of peroxisomes in the development and functions of the central nervous system, liver,...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-68134 | biostudies-arrayexpress
UnknownFrom Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Not available
S-EPMC5215561 | biostudies-literature
GenomicsGlobal transcriptional changes in the JJN3 myeloma cell line that occur as a result of treatment with 2 pyrrolobenzodiazepine (PBD) monomers
Global transcriptional changes in the JJN3 myeloma cell line that occur as a result of treatment with 2 pyrrolobenzodiazepine (PBD) monomers
PRJNA516213 | ENA
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