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ProteomicsQuantitative global proteomics of yeast PBP1 deletion mutants and their stress responses reveals glucose metabolism, translation and stress granule changes
The yeast protein PBP1 has been implicated in diverse pathways such as polyadenylation, translation, RNA-DNA hybrid formation, stress granule homeostasis, mitochondrial dysfunction, and TORC1 sequestration. Intriguingly, its deletion mitigates the toxicity of human neurodegeneration factors, but the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-12-23 | PXD003868 | Pride
Proteomics Pbp1 
GenomicsExpression data from wild-type, ccr4∆, and ccr4∆ pbp1∆ yeast cells.
Expression data from wild-type, ccr4∆, and ccr4∆ pbp1∆ yeast cells.
PRJNA816723 | ENA
TranscriptomicsAnalysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. Here we perform RIP-seq to determine the RNA interactors of Dcp1 (PB marker) and Pbp1 (SG marker) before and afte...
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9096 | biostudies-arrayexpress
TranscriptomicsPbp1 associates with Puf3 and promotes translation of its target mRNAs involved in mitochondrial biogenesis
Pbp1 (polyA-binding protein - binding protein 1) is a stress granule marker and polyglutamine expansions in its mammalian ortholog ataxin-2 have been linked to neurodegenerative conditions. Pbp1 was recently shown to form intracellular assemblies that function in the negative regulation of TORC1 sig...
ORGANISM(S): Saccharomyces cerevisiae 
2023-05-08 | GSE227356 | GEO
GenomicsPbp1 associates with Puf3 and promotes translation of its target mRNAs involved in mitochondrial biogenesis
Pbp1 associates with Puf3 and promotes translation of its target mRNAs involved in mitochondrial biogenesis
PRJNA944698 | ENA
GenomicsAnalysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
Analysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
PRJEB38404 | ENA
TranscriptomicsExpression data from wild-type, ccr4∆, and ccr4∆ pbp1∆ yeast cells.
Wild type, ccr4∆, ccr4∆ pbp1∆ cells were grown in YPD medium from log phase to stationary phase. Total RNAs ere extracted and subjected to microarray analysis.
ORGANISM(S): Saccharomyces cerevisiae 
2022-03-18 | GSE198743 | GEO
ProteomicsEssential PBP1-associated proteins of Trypanosoma brucei
Control of gene expression in kinetoplastids depends heavily on RNA-binding proteins that influence mRNA decay and translation. We previously showed that MKT1 interacts with PBP1, which in turn recruits LSM12 and poly(A) binding protein. MKT1 is recruited to mRNA by sequence-specific RNA-binding pro...
ORGANISM(S): Trypanosoma brucei 
2020-07-14 | PXD018576 | Pride
Trypanosoma Pbp1 Ataxin-2 Poly(a) binding protein Mkt1 Mrna 
UnknownPosttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.
Not available
S-EPMC387745 | biostudies-literature
UnknownPbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in Cryptococcus neoformans.
Not available
S-EPMC6811503 | biostudies-literature
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