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ProteomicsQuantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling
Rats are extensively used preclinical models for assessing drug pharmacokinetics (PK) and tissue distribution; however, a successful translation of the rat data requires information on the differences in drug metabolism and transport mechanisms between rats and humans. To partly fill this knowledge ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-02-05 | PXD039271 | Pride
Pbpk modeling Quantitative proteomics Drug metabolism Total protein approach Digoxin Drug transport Interspecies differences 
ProteomicsHepatic cytochrome P450 abundance and activity in the developing and adult Göttingen Minipig: pivotal data for PBPK modeling
The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. Due to developmental changes in pharmacokinetics (PK) and pharmacodynamics (PD), physiologically-based pharmacokinetic (PBPK) models are built to better predict drug exposure in childre...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-02-26 | PXD024158 | Pride
Mass spectrometry Protein abundance Göttingen minipig Cyp Pediatrics Ontogeny 
UnknownApplied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
Not available
S-EPMC5080648 | biostudies-literature
ModelsSugimoto2020 - minimal PBPK model of Fusion protein therapeutics
minimal PBPK modeling was established for better understanding of pharmacokinetic profile of investigational TFPs in the biotherapeutic discovery
2026-09-18 | MODEL2004300001 | BioModels
UnknownEscitalopram Dose Optimization During Pregnancy: A PBPK Modeling Approach.
Not available
S-EPMC12567279 | biostudies-literature
UnknownPhysiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates.
Not available
S-EPMC7355427 | biostudies-literature
UnknownExperimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery.
Not available
S-EPMC8576315 | biostudies-literature
ModelsGrzegorzewski2022 - PBPK model of dextromethorphan
Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan
2023-01-18 | MODEL2301090002 | BioModels
UnknownPhysiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification.
Not available
S-EPMC4613950 | biostudies-literature
UnknownClinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation.
Not available
S-EPMC9944674 | biostudies-literature
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