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GenomicsPbx IIBA ChIP-seq
Chromatin immunoprecipitation using pan-Pbx antibodies in second branchial arch cells from E11.5 mouse embryos detected by SOLiD sequencing
ORGANISM(S): Mus musculus 
2015-02-02 | E-MTAB-1633 | biostudies-arrayexpress
GenomicsPbx IIBA ChIP-seq
Pbx IIBA ChIP-seq
PRJEB1864 | ENA
ProteomicsMNX1-mediated Histone Modifications and PBX Family Role in MNX1-AML Leukemogenesis
The t(7;12) AML subtype in pediatric patients is associated with upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their relationship to the histone modifications previously observed to be mediated b...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-24 | PXD056378 | Pride
Pediatric acute myeloid leukemia Pbx T(7 12) Mnx1 
TranscriptomicsRNA-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 24 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). HOX transcription factors have been historically implicated in axial elongation, with their sequential activation playing a fu...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9773 | biostudies-arrayexpress
GenomicsGenome-wide distribution of Pbx1/2/3 in mouse cortex at embryonic day 15.5 [ChIP-seq]
We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2+/ sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre). Pbx1/2 mutants have three salient molecula...
ORGANISM(S): Mus musculus 
2016-03-12 | E-GEOD-79152 | biostudies-arrayexpress
GenomicsGenome-wide distribution of Pbx1/2/3 in mouse cortex at embryonic day 12.5 [ChIP-seq]
We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2+/ sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre). Pbx1/2 mutants have three salient molecula...
ORGANISM(S): Mus musculus 
2016-02-27 | E-GEOD-78720 | biostudies-arrayexpress
TranscriptomicsATAC-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). WNT signalling sustains both NMP expansion and PM differentiation, but the mechanism by which it distinguishes between these a...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9776 | biostudies-arrayexpress
GenomicsChIP-seq for Pbx on mouse second and posterior branchial arches at E11.5
Pbx ChIP-seq on mouse second branchial arches, and posterior branchial arches connected to outflow tract of the heart (PBA/OFT) at embryonic day (E) 11.5.
ORGANISM(S): Mus musculus 
2020-10-16 | E-MTAB-8608 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse control embryos and pbx2-MO;pbx4-MO embryos at 10 somites and at 18 somites.
Pbx homeodomain proteins have been implicated in the regulation of gene expression during muscle development. Whether Pbx proteins are required broadly for the regulation of muscle gene expression or are required for the expression of a specific subset of muscle gene expression is not known. We em...
ORGANISM(S): Danio rerio 
2008-06-16 | E-GEOD-8428 | biostudies-arrayexpress
TranscriptomicsPbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish
The basic helix-loop-helix factor Myod initiates skeletal muscle differentiation by directly and sequentially activating sets of muscle differentiation genes, including those encoding muscle contractile proteins. We hypothesize that Pbx homeodomain proteins direct Myod to a subset of its transcripti...
ORGANISM(S): Danio rerio 
2013-03-28 | E-GEOD-45532 | biostudies-arrayexpress
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