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ProteomicsMnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric t(7;12) Acute Myeloid Leukemia
Acute myeloid leukemia (AML) in children with cytogenetic aberrations like translocation t(7;12)(q36;p13) is associated with inferior outcome. The translocation can lead to a fusion transcript MNX1::ETV6 but also to activation of MNX1 transcription. We generated an AML mouse model by transplantatio...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-30 | PXD034416 | Pride
Aml Mnx1::etv6 Homeodomain T(7 12) Pediatric aml Mnx1 Methyl-transferases 
ProteomicsMNX1-mediated Histone Modifications and PBX Family Role in MNX1-AML Leukemogenesis
The t(7;12) AML subtype in pediatric patients is associated with upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their relationship to the histone modifications previously observed to be mediated b...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-24 | PXD056378 | Pride
Pediatric acute myeloid leukemia Pbx T(7 12) Mnx1 
UnknownLncRNA MNX1-AS1 promotes progression of intrahepatic cholangiocarcinoma through the MNX1/Hippo axis.
Not available
S-EPMC7581777 | biostudies-literature
GenomicsThe pioneer transcription factor PBX as a downstream target of MNX1 [ACT]
The pioneer transcription factor PBX as a downstream target of MNX1 [ACT]
PRJNA1124110 | ENA
GenomicsThe pioneer transcription factor PBX as a downstream target of MNX1 [ATAC]
The pioneer transcription factor PBX as a downstream target of MNX1 [ATAC]
PRJNA1124117 | ENA
GenomicsSingle cell analysis of MNX1 overexpression in hemogenic gastruloids
Single cell analysis of MNX1 overexpression in hemogenic gastruloids
PRJEB56088 | ENA
GenomicsMNX1 prevents somatostatin expression in human beta cells by repressing PERCC1
MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1
PRJNA1281531 | ENA
UnknownExpression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer.
Not available
S-EPMC6205149 | biostudies-literature
GenomicsThe pioneer transcription factor PBX as a downstream target of MNX1 [ATAC]
Recently we have identified the upregulation of the homebox domain protein MNX1 associated with the paediatric t(7;12) AML as the initiating event for Leukaemia in mice. We demonstrated that MNX1 triggers abnormal histone modifications, specifically H3K4me3 and H3K27me3, by interacting with SAM-depe...
ORGANISM(S): Mus musculus 
2025-04-24 | GSE269913 | GEO
OtherThe pioneer transcription factor PBX as a downstream target of MNX1 [ACT]
Recently we have identified the upregulation of the homebox domain protein MNX1 associated with the paediatric t(7;12) AML as the initiating event for Leukaemia in mice. We demonstrated that MNX1 triggers abnormal histone modifications, specifically H3K4me3 and H3K27me3, by interacting with SAM-depe...
ORGANISM(S): Mus musculus 
2025-04-24 | GSE269910 | GEO
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