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TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
ProteomicsDomains architecture and phospho-switches of eIF3e translation subunit control pollen tube growth and morphology
The eIF3e subunit form an octameric ribonucleoprotein complex to initiate translation, and its PCI domain engage in the assembly of the proteolytic 26S proteosome supercomplex. These two complexes are central in translation initiation and protein quality surveillance and turnover. However, how eIF3e...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2026-04-06 | PXD048337 | Pride
Eif3 Proteosome Ribosome profiling Translation initiation Polarity Ripseq Pollen tube Pci domain Phosphorylation 
TranscriptomicsChromatin immunoprecipitation in yeast for different affinity-tagged strains (two genotypes compared with wild type)
RNA immunoprecipitation from different affinity-tagged strains. Each hyb compared to a common total RNA.
ORGANISM(S): Schizosaccharomyces pombe 
2004-11-09 | E-MEXP-208 | biostudies-arrayexpress
UnknownThe eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes.
Not available
S-EPMC3315329 | biostudies-literature
UnknownStructural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes.
Not available
S-EPMC3973348 | biostudies-literature
UnknownThe PCI domains are "winged" HEAT domains.
Not available
S-EPMC9467303 | biostudies-literature
TranscriptomicsGene expression profiles of neonatal cardiomyocytes and immortalized heart muscle cells exposed to inflammatory stimuli
We used a transcriptomic approach to systematically compare the response to inflammatory stimuli for two murine cardiomyocyte models. Our results indicate that murine neonatal cardiomyocytes (NNC) are able to exhibit a pronounced response upon inflammatory stimuli, while HL-1 cells were predominantl...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-56584 | biostudies-arrayexpress
UnknownThe Impact of Kinase Insert Domain (KDR) Gene Polymorphism rs2305948 on Clopidogrel Resistance in Iraqi Patients Undergoing Elective Percutaneous Coronary Intervention (PCI).
Not available
S-EPMC7780779 | biostudies-literature
GenomicsIbrutinib induces a global chromatin reorganisation in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in developed countries. Ibrutinib (PCI-32765), a specific and irreversible inhibitor of Bruton's Tyrosine Kinase (BTK) represents a major step forward in the treatment of CLL. We have undertaken a detailed analysis of t...
ORGANISM(S): Homo sapiens 
2019-06-01 | E-MTAB-6410 | biostudies-arrayexpress
UnknownStructural biology of the PCI-protein fold.
Not available
S-EPMC3675071 | biostudies-literature
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