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ProteomicsTMT-MS of PCIF1 siRNAs treated RPE-1 cells
RPE-1 cells treated with the indicated siRNAs for 48 h were subjected to the tandem mass tag quantitative proteomics analysis.Carry out relative protein quantification analysis using tandem mass tag mass spectrometry in RPE-1 cells to investigate the mechanism underlying PCIF1 attenuates ciliation.
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD044338 | Pride
Pcif1 Rpe-1 Tmt-ms 
ProteomicsSERBP1–PCIF1 complex–controlled m6Am modification in S1HLGlu neurons is required for neuropathic pain in mice
Nerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional layer of gene regulation. However, the role of ...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD065634 |
Genomicsm6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling
m6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling
PRJNA1438204 | ENA
GenomicsPro-Seq of MEL624 control and PCIF1 KO cells
Pro-Seq of MEL624 control and PCIF1 KO cells
PRJNA506412 | ENA
Genomicsm6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling
m6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling
PRJNA1438080 | ENA
Genomicsm6A-seq data analysis of control and PCIF1 knockdown transcriptome
m6A-seq data analysis of control and PCIF1 knockdown transcriptome
PRJNA492247 | ENA
GenomicsEffect of PCIF1 knockdown on gene exppression in HeLa S3 cells
Effect of PCIF1 knockdown on gene exppression in HeLa S3 cells
PRJNA658999 | ENA
UnknownPCIF1, the only methyltransferase of N6,2-O-dimethyladenosine.
Not available
S-EPMC10544176 | biostudies-literature
Transcriptomicsm6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling
Skeletal development depends on the self-renewal and differentiation of MSCs. Emerging research underscores the regulatory functions of RNA methylation on bone homeostasis. Here, we show PCIF1, the N6,2′-O-dimethyladenosine (m6Am) methyltransferase, is essential for maintaining bone mass and promoti...
ORGANISM(S): Homo sapiens 
2026-03-19 | GSE324998 | GEO
Unknownm6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.
Not available
S-EPMC10965392 | biostudies-literature
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