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MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
ProteomicsMultiplex PRM quantitation of CD8a, CD4, LAG3, PD1, PD-L1 and PD-L2
Immuno-LC-PRM assay was developed to simultaneously quantify the expression levels of six immune markers (CD8A, CD4, LAG3, PD1, PD-L1 and PD-L2) using as little as 1-2 mg of fresh frozen tissue.
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD011152 | Pride
Prm. immuno-oncology Pd1 Pd-l1 and pd-l2 Lag3 Cd8 Cd4 
ProteomicsQuantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma.
LC-MS/MS targeted files submitted as support material for the paper: Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-21 | MSV000080433 | MassIVE
ProteomicsAnalysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
New therapeutics targeting immune checkpoint proteins have significantly advanced treatment of non-small cell lung cancer (NSCLC), but protein level quantitation of drug targets presents a critical problem. We used multiplexed, targeted mass spectrometry (MS) to quantify the immunotherapy target pr...
ORGANISM(S): Homo Sapiens 
2020-06-22 | PXD019061 | panorama
GenomicsA tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2
A tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2
PRJNA557163 | ENA
TranscriptomicsIntegrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines. DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-22208 | biostudies-arrayexpress
TranscriptomicsInterferon receptor signaling pathways regulating PD-L1 and PD-L2 expression
We studied the molecules involved in downstream signaling induced by interferons to regulate PD- L1 and PD-L2 expression using a shRNA screen, Western blot, mRNAexpression profiling, promoter truncation analysis and chromatin immunoprecipitation.These studies revealed that the interferon gamma-JAK1/...
ORGANISM(S): Homo sapiens 
2017-05-09 | GSE96619 | GEO
TranscriptomicsA tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2
A tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2
ORGANISM(S): Homo sapiens 
2019-07-30 | GSE135016 | GEO
UnknownHigh-affinity PD-1 molecules deliver improved interaction with PD-L1 and PD-L2.
Not available
S-EPMC6113430 | biostudies-literature
UnknownGATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors.
Not available
S-EPMC7271235 | biostudies-literature
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