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TranscriptomicsTranscription profiling of mouse CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells
Comparison of gene expression profile of CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells. Naive CD4+CD25-CD45RBhigh T cells were used as a reference for pair comparison with values from the three other subsets.
ORGANISM(S): Mus musculus 
2009-08-19 | E-MEXP-1343 | biostudies-arrayexpress
TranscriptomicsSingle-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients
We evaluated blood samples from 6 patients with metastatic melanoma treated with anti-LAG3+anti-PD1 (160+480 mg) in a phase I trial (NCT01968109) using single-cell RNA and T cell receptor (TCR) sequencing (scRNA+TCRαβ-seq, 10X 5') combined with other multiomics profiling (flow, cytokine, TCRb-seq) f...
ORGANISM(S): Homo sapiens 
2023-02-03 | E-MTAB-12733 | biostudies-arrayexpress
ProteomicsMultiplex PRM quantitation of CD8a, CD4, LAG3, PD1, PD-L1 and PD-L2
Immuno-LC-PRM assay was developed to simultaneously quantify the expression levels of six immune markers (CD8A, CD4, LAG3, PD1, PD-L1 and PD-L2) using as little as 1-2 mg of fresh frozen tissue.
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD011152 | Pride
Prm. immuno-oncology Pd1 Pd-l1 and pd-l2 Lag3 Cd8 Cd4 
GenomicsLAG3 marks activated but hyporesponsive NK cells
LAG3 marks activated but hyporesponsive NK cells
PRJNA1199557 | ENA
ProteomicsAPEX protemics of the inhibitory receptors CLTA-4, LAG-3 and TIM-3
APEX proteomics data of the vesicular proteome of the T cell inhibitory receptors CTLA-4, LAG3 and TIM3 as described in https://biorxiv.org/cgi/content/short/2023.07.21.550019v1
ORGANISM(S): Mus musculus (Mouse) 
2023-10-26 | PXD044064 | Pride
Mouse T cell Apex Inhibitory receptor 
TranscriptomicsExpression data of human tonsilar CD4 positive T cell subsets
Type 1 regulatory T (Tr1) cells are one of the regulatory T cell subsets that are characterized by the production of high amount of IL-10 and lack of FOXP3 expression. Lymphocyte-activation gene 3 (LAG3) is a CD4 homologue molecule and we have previously reported that LAG3 is expressed on IL-10 prod...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-73927 | biostudies-arrayexpress
GenomicsChromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks
Chromatin Capture Identifies SCARB1-LAG3 Proinflammatory Cardiovascular Disease Gene Networks
PRJNA434469 | ENA
GenomicsTranscriptional analysis of LAG3 deficient Tregs in an inflamed CNS
Transcriptional analysis of LAG3 deficient Tregs in an inflamed CNS
PRJNA668390 | ENA
GenomicsImmune Receptor Lag3 Deletion Alleviates Neurodegeneration Phenotypes in a Mouse Model of Alzheimer’s Disease
Immune Receptor Lag3 Deletion Alleviates Neurodegeneration Phenotypes in a Mouse Model of Alzheimer’s Disease
PRJNA1314557 | ENA
TranscriptomicsLAG3 marks activated but hyporesponsive NK cells
Natural Killer (NK) cells are critical for immunosurveillance. However, NK cells can become dysfunctional in contexts such as chronic stimulation by viral infections or cancer. NK cells often display an increased expression of immune checkpoint proteins (ICP) following chronic stimulation, and ICP b...
ORGANISM(S): Mus musculus 
2025-06-27 | GSE284572 | GEO
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