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ProteomicsImpaired cAMP Processivity by Phosphodiesterase-Protein Kinase A complexes in Acrodysostosis
Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities. Mutations in the 3’5’cyclic AMP (cAMP)-dependent Protein Kinase (PKA) type I regulatory subunit isoform α (RIα) and phosphodiesterase (PD...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2023-09-13 | PXD045088 | Pride
Amide hydrogen deuterium exchange mass spectrometry Acrodysostosis Processivity Protein kinase a Signal termination Allostery 
UnknownTreatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8).
Not available
S-EPMC8870644 | biostudies-literature
UnknownA yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition.
Not available
S-EPMC3743849 | biostudies-literature
UnknownStructure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia.
Not available
S-EPMC9293670 | biostudies-literature
UnknownPDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6.
Not available
S-EPMC5894499 | biostudies-literature
ProteomicsMultiplicity of regulatory subunit conformations define structural ensemble of reset Protein Kinase A holoenzyme
How Protein kinase A (PKA) is reset to a basal state following 3’5’cyclic adenosine monophosphate(cAMP)-mediated activation is unknown. Here we describe the mechanism of cAMP-PKA signal termination leading to reset of PKA by holoenzyme formation through the obligatory action of phosphodiesterases (P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-07-14 | PXD061315 | Pride
Reset Conformational dynamics Signal termination Phosphodiesterase Protein kinase a 
UnknownCloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
Not available
S-EPMC21190 | biostudies-literature
UnknownChanneling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.
Not available
S-EPMC5479052 | biostudies-literature
UnknownCharacterization of novel phosphodiesterases in the bovine ovarian follicle.
Not available
S-EPMC2849824 | biostudies-literature
UnknownStudying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.
Not available
S-EPMC5679091 | biostudies-literature
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