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ProteomicsImpaired cAMP Processivity by Phosphodiesterase-Protein Kinase A complexes in Acrodysostosis
Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities. Mutations in the 3’5’cyclic AMP (cAMP)-dependent Protein Kinase (PKA) type I regulatory subunit isoform α (RIα) and phosphodiesterase (PD...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2023-09-13 | PXD045088 | Pride
Amide hydrogen deuterium exchange mass spectrometry Acrodysostosis Processivity Protein kinase a Signal termination Allostery 
ProteomicsCDK13 cooperates with CDK12 to control global RNA polymerase II processivity
The RNA polymerase II (POLII) driven transcription cycle is tightly regulated at distinct checkpoints through cyclin dependent kinases (CDKs) and their cognate Cyclins. The molecular events underpinning transcriptional elongation and processivity and CDK-Cyclins involved remain poorly understood. Us...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015453 | Pride
Cdk13 Cdk12 Phosphoproteomics Polymerase 
GenomicsSpt4 promotes Pol I processivity and transcription elongation
Spt4 promotes Pol I processivity and transcription elongation
PRJNA702517 | ENA
UnknownmTORC1 Enhances Early Phase Ribosome Processivity.
Not available
S-EPMC7325874 | biostudies-literature
GenomicsCTCF N-terminal Domain Regulates Clustered Protocadherin Gene Expression by Enhancing Cohesin Processivity [ChIP-seq]
CTCF N-terminal Domain Regulates Clustered Protocadherin Gene Expression by Enhancing Cohesin Processivity [ChIP-seq]
PRJNA1204916 | ENA
UnknownSequence- and species-dependence of proteasomal processivity.
Not available
S-EPMC3423507 | biostudies-literature
ProteomicsIn vitro synthesis of 32 translation-factor proteins from a single template reveals impaired ribosomal processivity
The Protein synthesis Using Recombinant Elements (PURE) system enables transcription and translation of a DNA template from purified components. Therefore, the PURE system-catalyzed generation of RNAs and proteins constituting the PURE system itself represents a major challenge toward a self-replica...
ORGANISM(S): Escherichia Coli 
2021-09-06 | PXD020877 | panorama
UnknownProcessivity, synergism, and substrate specificity of Thermobifida fusca Cel6B.
Not available
S-EPMC2772456 | biostudies-literature
UnknownProcessivity of cellobiohydrolases is limited by the substrate.
Not available
S-EPMC3012971 | biostudies-literature
UnknownChromatinization modulates topoisomerase II processivity.
Not available
S-EPMC10611788 | biostudies-literature
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