Sort   by:  
 Page size 
TranscriptomicsDose-dependent dual roles of PDGF-BB–PDGFR-? in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis
Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-46564 | biostudies-arrayexpress
TranscriptomicsGene expression profiling regulated by PDGF in pBSMCs
To explore global molecular changes in smooth muscle in response to PDGFR activation, primary human bladder smooth muscle cells were treated with 1 nM PDGF-BB (hereafter PDGF) for 0, 4 or 24 h. Total RNA were prepared, and analyzed using expression profiling, and subjected to bioinformatic and funct...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-52488 | biostudies-arrayexpress
TranscriptomicsPDGF stimulation kinetics
Subconfluent AG01518 fibroblasts were starved for 16 hours in the presence of 0.1% BSA, and then stimulated for 1, 4, 10 or 24 hours with PDGF-BB (10 ng/ml in starvation medium), or left untreated for the same periods of time. Total RNA was isolated using the RNeasy kit (Qiagen). The RNA quality was...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1484 | biostudies-arrayexpress
TranscriptomicsEffect of interleukin-1 and PDGF-DD on SMCs
This experiment tests the hypothesis that interleukin-1 promotes SMC phenotypic modulation to a distinct inflammatory state relative to the growth factor PDGF-DD. Cultured rat aortic smooth muscle cells were treated with IL-1b (2.5 ng/mL) or vehicle (0.1% BSA and 10 mM acetic acid) or PDGF-DD (30 ng...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-31080 | biostudies-arrayexpress
TranscriptomicsSurvival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3b phosphorylation
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report here a novel finding that PDGF...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-19207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation)
We compared the gene expression profiles of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation). Cells grown in the presence of FGF-2 were used as a reference.
ORGANISM(S): Rattus norvegicus 
2006-03-15 | E-TABM-39 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts stimulated with PDGF-BB or b-FGF
We analyzed gene expression in human fibroblasts stimulated by platelet-derived growth factor-BB (PDGF-BB) or basic fibroblast growth factor (bFGF) for 1h and 24h. The results of two independent experiments were merged. SAM analysis identified 116 relevant probe sets. Hierarchical clustering of thes...
ORGANISM(S): Homo sapiens 
2009-03-20 | E-GEOD-14256 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77419 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77423 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U87 wild type, neo-resistant and PDGF-A dominant negative U87 gliobastoma cells to identify PDGF-dependent patterns of gene expression
Overall study: Identification of PDGF-dependent patterns of gene expression in U87 glioblastoma cells. RNA was obtained from triplicate dishes of 5 different groups of U87 cells, each (total 15) analyzed with one U95 microarray chip.,Three different comparisons were made:,1) Clone 3.1 (34580-34582) ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-1923 | biostudies-arrayexpress
Sort   by:  
 Page size