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ProteomicsA Network G Protein Gai Signaling Partners is Revealed by Proximity Labeling Proteomics and Includes PDZ-RhoGEF
G protein-coupled receptors (GPCRs) that couple to the Gi family of G proteins are key regulators of cell and tissue physiology. Our previous work has revealed new roles for Gαi in regulating the migration of neutrophils and fibrosarcoma cells downstream of activated chemoattractant receptors. We us...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD027905 | Pride
Gαi proteins Proximity labeling Pdz-rhogef Cell-migration Interactome Mass spectrometry Gpcr signaling 
UnknownOncogenic Gαq activates RhoJ through PDZ-RhoGEF.
Not available
S-EPMC10647656 | biostudies-literature
UnknownSecondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.
Not available
S-EPMC4672773 | biostudies-literature
UnknownStructural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.
Not available
S-EPMC5367461 | biostudies-literature
UnknownPDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival.
Not available
S-EPMC6140379 | biostudies-literature
UnknownThe amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.
Not available
S-EPMC2728795 | biostudies-literature
UnknownThe Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.
Not available
S-EPMC4709268 | biostudies-literature
UnknownIdentification of <i>ARHGEF11</i> (PDZ-RhoGEF) as an in vivo regulator of synapses and cognition.
Not available
S-EPMC11789018 | biostudies-literature
UnknownBinding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.
Not available
S-EPMC2871504 | biostudies-literature
UnknownGαs directly drives PDZ-RhoGEF signaling to Cdc42.
Not available
S-EPMC7863908 | biostudies-literature
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