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MetabolomicsGeneration of a chromosome-scale genome assembly of the insect-repellent terpenoid-producing Lamiaceae species, Callicarpa americana

BACKGROUND: Plants exhibit wide chemical diversity due to the production of specialized metabolites that function as pollinator attractants, defensive compounds, and signaling molecules. Lamiaceae (mints) are known for their chemodiversity and have been cultivated for use as culi...

2020-12-04 | MTBLS1983 | MetaboLights
MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
UnknownTotal Body Water Dynamics Estimated with Bioelectrical Impedance Vector Analysis and B-Type Natriuretic Peptide After Exposure to Hypobaric Hypoxia: A Field Study.
Not available
S-EPMC5743030 | biostudies-literature
ProteomicsReduction of ZFX levels decreases histone H4 acetylation and increases the pause ratio at target promoters
The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ~200-250bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044709 | Pride
Elongation Turboid Pol2 pausing Zfx Transcription 
TranscriptomicsTranscription profiling of Schistosoma lifecycle
Transcriptome analysis throughout the lifecycle of the helminth Schistosoma mansoni.
ORGANISM(S): Schistosoma mansoni 
2009-12-31 | E-MEXP-2094 | biostudies-arrayexpress
TranscriptomicsATAC-seq data of Amphimedon queenslandica (Demosponge species) through eight developmental stages, from white stage (cleavage) to adult
We report a comprehensive DNA accessibility profile of the Demosponge species Amphimedon queenslandica using Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) through six embryonic developmental stages, a larval stage and adult stage. We assessed the dynamics of chromatin accessi...
ORGANISM(S): Amphimedon queenslandica 
2021-10-10 | E-MTAB-10203 | biostudies-arrayexpress
GenomicsGenome-wide map of PCL2 (Polycomb-like 2) enrichment in undifferentiated mouse embryonic stem cells (ESCs)
In total 8,736,191 reads from IP fraction and 9,958,984 reads from Wash fraction uniquely mapped to the mouse genome (mm9). Settings for enrichment analysis: maxSpacing=500; minHits=20; minPeakHits=6; minRatio=3. 4,701 regions have been identified as enriched in the IP fraction. In order to get a ro...
ORGANISM(S): Mus musculus 
2010-02-05 | E-GEOD-16526 | biostudies-arrayexpress
TranscriptomicsMAFB ChIPseq in Human EndoCBH2 cells
The intent of this experiment was to determine MAFB binding sites in human pancreatic beta cells. This is particularly relevant as MAFB is not expressed in mature rodent beta cells; thus, it may perform unique functions in human. Sequencing was performed following IP with an anti-MAFB antibody using...
ORGANISM(S): Homo sapiens 
2020-03-17 | E-MTAB-8612 | biostudies-arrayexpress
MetabolomicsA shotgun metabolomics approach to characterize the dissolved organic matter pool in the Samail Ophiolite aquifer
The process of serpentinization has been implicated in supporting life on both early Earth and other worlds in our Solar System. While numerous studies have provided clues to the survival strategies of microbial communities in serpentinizing environments on modern Earth, characterizing microbial act...
2023-03-02 | MTBLS6081 | MetaboLights
ProteomicsA proteomic signature of oocyte quality from models of varying oocyte developmental competence
Within the ovarian follicle, mammalian oocytes acquire the necessary molecular machinery for successful fertilisation and embryonic development. In the absence of the follicle, oocytes matured in vitro (IVM) using traditional IVM show compromised developmental competence, resulting in poorer outcome...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-24 | PXD073269 | Pride
Capacitation-ivm (capa-ivm) Assisted reproductive technologies Folliculogenesis Oocyte Cumulus cell In vitro maturation (ivm) 
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