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ProteomicsReduction of ZFX levels decreases histone H4 acetylation and increases the pause ratio at target promoters
The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ~200-250bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044709 | Pride
Elongation Turboid Pol2 pausing Zfx Transcription 
TranscriptomicsZfx controls BCR-induced proliferation and survival of B lymphocytes
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeos...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-13547 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of embryonic and hematopoietic stem cells lacking the transcription factor Zfx to provide insight into the role of Zfx in embryonic and adult stem cell self-renewal
Stem cells (SC) exhibit a unique capacity for self-renewal in an undifferentiated state. It is unclear whether the self-renewal of pluripotent embryonic SC (ESC) and of tissue-specific adult SC such as hematopoietic SC (HSC) is controlled by common mechanisms. The deletion of transcription factor Zf...
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-7069 | biostudies-arrayexpress
TranscriptomicsZfx controls self-renewal of human embryonic stem cells
Previously, we identified the transcription factor Zfx as a key regulator of self-renewal in murine ESCs. Here we extend those findings to human ESCs. Zfx knockdown in hESCs hindered clonal growth and decreased colony size after serial replating. Zfx overexpression enhanced clone formation, increase...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-29784 | biostudies-arrayexpress
TranscriptomicsEffect of ZFX shRNA mediated knockdown in the human AML cell line NOMO-1
Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) maintain the undifferentiated phenotype and proliferative capacity of their respective cells of origin, hematopoietic stem/progenitor cells and immature thymocytes. The mechanisms that maintain these progenitor-like characterist...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-43021 | biostudies-arrayexpress
GenomicsGenome wide maps of ZFX binding in human leukemia cell lines
Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) maintain the undifferentiated phenotype and proliferative capacity of their respective cells of origin, hematopoietic stem/progenitor cells and immature thymocytes. The mechanisms that maintain these progenitor-like characterist...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-43147 | biostudies-arrayexpress
GenomicsGene expression profiling of MC38 Zfx KO clones in vitro
Gene expression profiling of MC38 Zfx KO clones in vitro
PRJNA1159820 | ENA
GenomicsGene expression profiling of MC38 Zfx KO clones in vivo
Gene expression profiling of MC38 Zfx KO clones in vivo
PRJNA1159822 | ENA
GenomicsThe differentially expressed genes profile upon ZFX silencing in CML CD34+ cells
The differentially expressed genes profile upon ZFX silencing in CML CD34+ cells
PRJNA1006416 | ENA
UnknownDifferential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes
Not available
S-EPMC6305825 | biostudies-literature
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