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GenomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites (ChIP-seq KYSE150 cell line)
We have mapped binding sites for the histone demethylase, JMJD2C/KDM4C/GASC1, and the effect of JMJD2C depletion on H3K9me3 and H3K36me3 distributions in KYSE150 cells. The human esophageal carcinoma cell line, KYSE150, contains an amplification of the JMJD2C locus. ChIP-seq was performed using chr...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53938 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Wheat-Phytase transgenic plants vs a non-transgenic control line at three different developmental stages of the seed
A transgenic wheat line was compared for gene expression patterns to a non-transgenic control line at three different developmental stages of the seed. The three successive developmental stages were also compared for each of the two lines. Thus, a factorial experiment with three developmental stages...
ORGANISM(S): Triticum aestivum 
2005-07-01 | E-MEXP-368 | biostudies-arrayexpress
TranscriptomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites (Affymetrix microarray analysis)
We have mapped transcriptional changes after depletion of the histone demethylases JMJD2C/GASC1/KDM4C and JMJD2A/KDM4A alone or in combination in the esophageal squamous carcinoma cell line, KYSE150. The KYSE150 cell line contains an amplification of the JMJD2C locus. RNA was extracted from KYSE150 ...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53892 | biostudies-arrayexpress
GenomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites (ChIP-seq MEFs)
We have mapped binding sites for the histone demethylase, Jmjd2c/Kdm4c/Gasc1, in mouse embryonic fibroblasts (MEFs) and the impact of Jmjd2c depletion on H3K9me3 and H3K36me3 distributions. ChIP-seq was performed using antibodies recognizing Jmjd2c, H3K9me3 or H3K36me3. Chromatin was obtained from c...
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-53939 | biostudies-arrayexpress
GenomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites (ChIP-seq ESCs)
We have mapped binding sites for the histone demethylase, Jmjd2c/Kdm4c/Gasc1, in mouse embryonic stem cells (ESCs). ChIP-seq was performed using an antibody recognizing Jmjd2c. Chromatin was obtained from conditional Jmjd2c knockout ESCs cultured in the absence or presence of OHT to induce activatio...
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-53936 | biostudies-arrayexpress
TranscriptomicsVoluntary exercise suppresses tumor growth through exercise-directed recruitment and intratumoral infiltration of NK cells
Voluntary exercise reduces the risk of cancer and lowers the risk of disease recurrence. Yet the mechanisms for this protection remain to be elucidated. Here we demonstrate that exercise halves tumor growth through an exercise-dependent mobilization and intratumoral infiltration of NK cells in malig...
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-62628 | biostudies-arrayexpress
TranscriptomicsExpression data from lack of DNA topoisomerase I, DNA topoisomerase II and complete lack of both topoisomerases
Here we dissect the transcriptional response in S. cerevisiae cells lacking DNA topoisomerases. We use microarray technology coupled with a functional genomics approach and demonstrate intimate connections between topoisomerase dependency, promoter chromatin architecture and gene transcription. Our ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-31 | E-GEOD-22809 | biostudies-arrayexpress
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
GenomicsThe Demethylase JMJD2C/KDM4C Localizes to H3K4me3 Positive Transcription Start Sites
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-28332 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Embryonic Stem Cell Derived Serotonin Neurons
The rhesus embryonic stem cell line 366.4 differentiates into serotonin neurons. RNA was extracted from ESC colonies, embryoid body (Ebs), Neurospheres in selection (N1), Proliferating serotonin neurons (N2) and differentiating serotonin neurons (N3). RNA was labeled with Enzo biotin labelling kit a...
ORGANISM(S): Macaca mulatta 
2010-04-08 | E-GEOD-16168 | biostudies-arrayexpress
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