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MetabolomicsUntargeted Lipidomics Profiling Provides Novel Insights into Pediatric Patients with Sepsis: An Exploratory Study

Background: The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes in adults sepsis, comprehensive investigations into plasma lipidomic alteratio...

2025-07-05 | MTBLS12058 | MetaboLights
TranscriptomicsTranscriptional instability in sepsis
The temporal evolution of sepsis was monitored by transcriptional profiling of five critically ill children with meningococcal sepsis and sepsis-induced multiple organ failure. Blood was sampled at 6 time points during the first 48 hours of their admission to pediatric intensive care, where the chil...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-MEXP-3850 | biostudies-arrayexpress
TranscriptomicsWhole blood mRNA transcription profiling of host immune changes in neonatal sepsis during vancomycin therapy
The purpose of this study was to investigate changes in host gene expression profiles of neonatal infants with sepsis prior to the initiation of and during vancomycin therapy, to identify treatment-responsive genes and signature pathways associated with recovery from neonatal sepsis. The study analy...
ORGANISM(S): Homo sapiens 
2025-11-25 | E-MTAB-15687 | biostudies-arrayexpress
TranscriptomicsAn integrated transcriptome and expressed variant analysis of sepsis survival and death
Background: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at gr...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-63042 | biostudies-arrayexpress
ProteomicsProteomic analysis identified age-associated prognostic biomarkers in pneumonia-derived pediatric sepsis
Pediatric sepsis is a leading cause of mortality in children across the world. Within pediatric sepsis, how developmental age-specific host immune response impact on the occurrence and development of pediatric sepsis is still unknown, especially between infants and toddlers, which were the major sus...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026656 | Pride
Pediatric sepsis Picu 
UnknownOutcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.
Not available
S-EPMC9524404 | biostudies-literature
TranscriptomicsTranscription profiling ofhuman pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum
Normal children, children with SIRS, children with sepsis, and children with septic shock. Objectives: To advance our biological understanding of pediatric septic shock, we measured the genome-level expression profiles of critically ill children representing the systemic inflammatory response syndro...
ORGANISM(S): Homo sapiens 
2009-01-05 | E-GEOD-13904 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SIRS and septic shock patients reveals
Goal of the experiment: To identify correlated genes, pathways and groups of patients with systemic inflammatory response syndrome and septic shock that is indicative of biologically important processes active in these patients. Background: We measured gene expression levels and profiles of childr...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4607 | biostudies-arrayexpress
UnknownComparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.
Not available
S-EPMC5399539 | biostudies-literature
GenomicsLong noncoding RNA and messenger RNA abnormalities in pediatric sepsis
Long noncoding RNA and messenger RNA abnormalities in pediatric sepsis
PRJNA606469 | ENA
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