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ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo sapiens (Human) 
2016-02-16 | PXD001952 | Pride
Human mesenchymal stem cells Label-free quantification 
ProteomicsViperin; regulating chondrogenic differentiation via CXCL10 protein secretion
Mutations in the RMRP gene are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in the RMRP gene lead to skeletal dysplasia. Viperin is a known substrate of RMRP. Sinc...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD006999 | Pride
Mouse Viperin Chondrogenic differentiation 
MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
MetabolomicsDetermining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament disease

OBJECTIVES: This study used hydrogen nuclear magnetic resonance spectroscopy (1H NMR) for the first-time to examine differences in the metabolomic profile of stifle joint synovial fluid from dogs with cranial cruciate ligament rupture with and without meniscal injuries, in order ...

2025-08-14 | MTBLS6050 | MetaboLights
MetabolomicsMetabolomic and Proteomic Stratification of Equine Osteoarthritis

Osteoarthritis (OA) is characterised by loss of articular cartilage, synovial membrane dysfunction and subchondral sclerosis. Few studies have used a global approach to stratify equine synovial fluid (SF) molecular profiles according to OA severity. SF was collected from 58 metacarpophalangeal (M...

2025-10-16 | MTBLS1645 | MetaboLights
ProteomicsEvaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Neurological Disorders
This study evaluated and compared three sample preparation strategies for proteomic analysis of equine cerebrospinal fluid (CSF): native in-solution digestion, the ProteoMiner™ Small-Capacity Enrichment Kit (Bio-Rad®), and the PreOmics Enrich-iST™ Kit (PreOmics®). CSF is in direct contact with the c...
ORGANISM(S): Equus caballus (Horse) 
2026-04-13 | PXD063239 | Pride
Cerebrospinal fluid (csf)  proteomics  native digestion  proteominer™ small-capacity enrichment kit  preomics enrich-ist™  liquid chromatography with tandem mass spectrometry (lc-ms/ms) 
TranscriptomicsRNASeq of musculoskeletal ageing using human mesenchymal stem cells and their tissue constructs
Human bone-marrow-derived mesenchymal stem cells from young and old donors and tenogenic, chondrogenic and osteogenic constructs derived from these were subject to RNASeq and miRNASeq. We wished to identify common pathways of musculoskeletal ageing.
ORGANISM(S): Homo sapiens 
2016-12-28 | E-MTAB-4879 | biostudies-arrayexpress
TranscriptomicsmiRNASeq of musculoskeletal ageing using human mesenchymal stem cells and their tissue constructs
Human bone-marrow-derived mesenchymal stem cells from young and old donors and tenogenic, chondrogenic and osteogenic constructs derived from these were subject to RNASeq and miRNASeq. We wished to identify common pathways of musculoskeletal ageing.
ORGANISM(S): Homo sapiens 
2016-11-01 | E-MTAB-3427 | biostudies-arrayexpress
TranscriptomicsSmall non-coding RNAs as biomarkers of musculoskeletal ageing and osteoarthritis
Mouse serum and joint small RNAs from young, old and a post traumatic model of osteoarthritis.
ORGANISM(S): Mus musculus 
2017-12-12 | E-MTAB-4878 | biostudies-arrayexpress
ProteomicsRibosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3
Ribosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3 and control condition was assessed.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046114 | Pride
Ribosomal proteome Tgfb Sw1353 
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