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TranscriptomicsDifferentiation of human embryonic stem cells towards hepatocytes
To understand in detail the molecular phases that occur during the differentiation of human embryonic stem cells to hepatocyte-like cells we performed an RNA-seq time course of the stages of differentiation across the 21 day differentiation time course. We used a chemically defined (serum-free) prot...
ORGANISM(S): Homo sapiens 
2017-04-28 | E-GEOD-70741 | biostudies-arrayexpress
TranscriptomicsTranscription profi;ing of mouse induced pluripotent stem cells vs MEF cells to investigate culturing conditions
We present a robust serum-free system for the rapid and efficient reprogramming of mouse somatic cells by Oct4, Sox2 and Klf4. The elimination of fetal bovine serum and oncogene c-Myc allowed reprogramming cells to be detected as early as Day 2 and reached greater than 10% of the population at Day ...
ORGANISM(S): Mus musculus 
2009-03-28 | E-GEOD-15267 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile for knocking down Tet1 in pre-iPSCs culturing in Vc medium.
Tet1 is a hydroxylase known for its role in the conversion of 5-methylcytosines (5mC) to 5-hydroxymethylcytosines (5hmC) involved in the possible active demethylation process and gene expression regulation. As somatic cell reprogramming involves the re-activation of pluripotency genes and the silenc...
ORGANISM(S): Mus musculus 
2013-10-27 | E-GEOD-48206 | biostudies-arrayexpress
TranscriptomicsDNA microarrays of 4 human iPSC cell lines and the ESC cell line H9
Documents of DNA expression of 4 human induced pluripotent stem cell (iPSC) lines from umbilical cord mesenchymal cells (UMCs) and amniotic mesenchymal cells (AMCs). We used microarrays to identify similarity between 4 iPSC cell lines and the human embryonic stem cell (ESC) line H9. 2 AMC iPSC cell ...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-20581 | biostudies-arrayexpress
Transcriptomicsc-Jun impedes somatic cell reprogramming by activating mesenchymal core regulators and suppressing pluripotent ones
The somatic cell fate can be converted to tumor or pluripotent ones by ectopic expression of transcription factors in vitro and in vivo. Many oncogenic transcription factors are known to mediate both fates as they share similar proliferative and metabolic properties. Paradoxically, we found c-Jun as...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-50776 | biostudies-arrayexpress
ProteomicsCell fate decision by a morphogen-transcription factor-chromatin modifier axis
The IP-MS data includes SALL4 IP-MS data with or without BMP4 treatment at day 3 of JGES reprogramming, each group contain 3 repeats.
ORGANISM(S): Mus Musculus 
PXD051433 |
TranscriptomicsMolecular mechanisms underlying reprogramming of mouse fibroblasts into pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE21062: DNA microarrays of three shRNA control iPS clones (Ctrl 2,3,4) and shECAD iPS clones (shECAD 4,8,9) GSE21064: DNA microarrays of SKOM transduced MEFs with added Tgfb1 or co-expressing Snail Refer to individual Series
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21067 | biostudies-arrayexpress
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
PXD026208 |
TranscriptomicsDNA microarrays (time course) of MEFs transduced with SKO plus HDAC7 or MEF2C
Overexpression HDAC7 can enhance iPS efficiency in SKO by supressing MEF2 factors We used microarrays to identify changes induced by overexpression of HDAC7 or MEF2C. MEFs were transduced with SKO plus HDAC7 or MEF2C compared to SKO plus empty vector(Flag), GFP as controls. TRIZOL cell lysates were ...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-23692 | biostudies-arrayexpress
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