Sort   by:  
 Page size 
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [ChIP-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51004 | biostudies-arrayexpress
GenomicsDistinct epigenomic landscapes of pluripotent and lineage-committed human cells
Human embryonic stem cells share identical genomic sequences with other lineage-committed cells yet possess the remarkable properties of self-renewal and pluripotency. It has been proposed that epigenetic regulatory mechanisms, involving DNA methylation and various chromatin modifications, are at l...
ORGANISM(S): Homo sapiens 
2009-10-13 | E-GEOD-17917 | biostudies-arrayexpress
GenomicsChromatin States in Human ES Cells Reveal Key Regulatory Sequences and Genes Involved in Pluripotency and Self-renewal
Human embryonic stem cells (hESCs) are offering a new therapeutic approach because of their unique ability to proliferate indefinitely in vitro and differentiate into multiple cell types. However, our understanding of the molecular mechanisms of pluripotency and self-renewal remain incomplete. To el...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-18292 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66953 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-73021 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [4C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66950 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional 4C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-72958 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [Hi-C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66952 | biostudies-arrayexpress
GenomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [ChIP-Seq]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66951 | biostudies-arrayexpress
Sort   by:  
 Page size