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ProteomicsContribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
Peptides generated by proteasome-catalyzed splicing of non-contiguous amino acid sequences have been shown to constitute a source of non-templated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8+ T cells are key mediators of human i...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2019-11-25 | PXD015489 | Pride
Spliced epitope Peptide splicing Viral escape Mass spectrometry Cd8+ t cell Epitope discovery Proteasome Human leukocyte antigen Immunopeptidome Human immunodeficiency virus 
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Lipidomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11523 | MetaboLights
UnknownManipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy.
Not available
S-EPMC7824126 | biostudies-literature
UnknownTuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.
Not available
S-EPMC7224568 | biostudies-literature
UnknownMemory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.
Not available
S-EPMC8259322 | biostudies-literature
UnknownAcquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
Not available
S-EPMC12557794 | biostudies-literature
UnknownIdentification and functional characterization of CD8+ T regulatory cells in type 1 diabetes patients.
Not available
S-EPMC6334945 | biostudies-literature
UnknownTargeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells.
Not available
S-EPMC10940689 | biostudies-literature
TranscriptomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication
RNA-seq of human cells Edited using CRISPR vs parental and Unedited control. We identified a rare homozygous intronic variant in the ATP2B1 locus (rs111337717; chr12:89643729, T>C) that is associated with the severity of COVID-19 (i.e., symptomatic versus asymptomatic patients). Next, we employed ...
ORGANISM(S): Homo sapiens 
2024-05-13 | E-MTAB-13916 | biostudies-arrayexpress
UnknownA single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells.
Not available
S-EPMC11574467 | biostudies-literature
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