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ProteomicsListeria monocytogenes exploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection
Mitochondrial function adapts to cellular demands and is affected by the ability of the organelle to undergo fusion and fission in response to physiological and non-physiological cues. We previously showed that infection with the human bacterial pathogen Listeria monocytogenes elicits transient mito...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD014667 | Pride
Micos complex Human Listeria monocytogenes Mitochondria Mic10 
TranscriptomicsGene expression variation in lymphocyte subpopulations in response to low dose of ionizing radiations
Lymphocytes are the standard cell of a majority of biodosimetry approaches because of their availability and radiosensitivity. But progresses remain to be performed to bring down the minimum threshold of dose sensitivity. To find a lymphocyte subtype able to respond to low doses of ionizing radiatio...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-6978 | biostudies-arrayexpress
ProteomicsISG15 counteracts Listeria monocytogenes infection
ISG15 is primarily documented as an interferon-stimulated, ubiquitin-like protein (ubl), which has anti-viral activity. Although ISG15 was the founding member of the ubl protein family, very little is known about its function. We have found that ISG15 expression in non-phagocytic cells is dramatic...
ORGANISM(S): Homo sapiens (Human) 
2015-07-24 | PXD001805 | Pride
Interferon Listeria Silac Isg15 
ProteomicsRapid High-Throughput Antibody Analysis Using Microwave-Assisted Digestion
Monoclonal antibodies (mAbs) are a major class of biotherapeutic proteins that have been extensively developed over the past decade, resulting in improved standards of care for multiple diseases. Regulatory agencies recommend a Quality by Design (QbD) approach for manufacturing therapeutic proteins,...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD067893 | Pride
Data independent acquisition Post translational modifications Antibodies Data dependent acquisition Microwave-assisted digestion 
TranscriptomicsIn vivo transcriptome of Listeria monocytogenes EGDe
Time course study of the mouse infection by comparing the genomic transcriptional patterns of Listeria monocytogenes EGDe grown under laboratory conditions (exponential growth phase) with that of in vivo-grown bacteria (in mouse spleens) over three days of infection. Time course study of the mouse i...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-06-25 | E-GEOD-13057 | biostudies-arrayexpress
ProteomicsBeauveria bassiana manipulates host plant physiology to promote growth and defense
During plant life, roots support beneficial associations with soil inhabiting microbes, mainly fungi and bacteria. Increasing evidence suggests that plant-associated microorganisms can promote plant growth and expand immune functions of the plant host. The beneficial entomopathogenic fungus Beauveri...
ORGANISM(S): Solanum lycopersicum 
2023-05-09 | PXD029422 | Pride
Proteomics Beauveria bassiana Tomato leaves Solanum lycopersicum l. Mass-spectrometry 
TranscriptomicsComparative genomic hybridization by array of east haploid and heterozygous essential deletion pools treated with compounds synergistic with fluconazole to identify sensitive and resistant mutants
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-07 | E-MTAB-394 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptome between free-living and symbiotic cells of Frankia alni ACN14a
The actinobacteria Frankia alni is able to induce the formation of nodules on the root of a large spectrum of actinorhizal plants, where it converts dinitrogen to ammonia in exchange for plant photosynthates. In the present study, transcriptional analyses were performed on nitrogen-replete free-livi...
ORGANISM(S): Frankia alni ACN14a 
2010-09-12 | E-GEOD-18190 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Zea mays chloroplast extracts prepared from wild type and PPR4-deficient tissue
Co-immunoprecipitation of the maize pentatricopeptide protein PPR4 and extraction of bound RNA. RNA is labelled and hybridized to a maize chloroplast genome tiling array in order to identify target RNA species of PPR4.
ORGANISM(S): Zea mays 
2022-11-22 | E-MEXP-716 | biostudies-arrayexpress
TranscriptomicsIGR_CREMEC_CGH_STYDY_LL
Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and might be more relevant preclinical models to evaluate effective therapeutic agents. Our consortium joins efforts to extensively develop and characterize a new collection of patient-derived colorectal ...
ORGANISM(S): Homo sapiens 
2012-07-27 | E-MTAB-992 | biostudies-arrayexpress
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