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TranscriptomicsFoxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed by Agilent arrays
Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical genes, i.e., Rspo1 and Wnt4. Here we report expression prof...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12942 | biostudies-arrayexpress
UnknownTris(1,2-diamino-ethane)-nickel(II) hexa-fluoridosilicate.
Not available
S-EPMC3009077 | biostudies-literature
TranscriptomicsConstitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice
During female reproductive life, the reserve of ovarian follicles is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. We asked if overexpression of a constitutively active FOXO3 protein can increase long-lasting ovarian reproductive...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-45389 | biostudies-arrayexpress
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
UnknownFinite mixture clustering of human tissues with different levels of IGF-1 splice variants mRNA transcripts.
Not available
S-EPMC4570607 | biostudies-literature
UnknownMechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis.
Not available
S-EPMC10242967 | biostudies-literature
TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
UnknownAccuracy of Critical Care Pain Observation Tool and Behavioral Pain Scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study.
Not available
S-EPMC5100216 | biostudies-literature
UnknownPrevalence and clinical consequences of atelectasis in SARS-CoV-2 pneumonia: a computed tomography retrospective cohort study.
Not available
S-EPMC8369136 | biostudies-literature
UnknownThe use of tier three therapies in acute brain injured patients: Insight from the Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes observational study.
Not available
S-EPMC11798370 | biostudies-literature
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