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MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
TranscriptomicsThe MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila
Active genes on the X chromosome of Drosophila males are upregulated by the Male-specific lethal (MSL) complex containing five MSL proteins and two non-coding roX RNAs. To probe the targeting mechanism, we have solved the structure of the MSL3 chromodomain, designed point mutations in key residues t...
ORGANISM(S): Drosophila melanogaster 
2008-11-18 | E-GEOD-11817 | biostudies-arrayexpress
ModelsLiu1999_PulsatileSecretion
This a model from the article: A dynamical model for the pubsatile secretion of the hypothalamo-pituitary-adrenal axis. Yi-wei Liu, Zhi-Hong Hu, Jian-Hua Peng and Bing-Zheng Liu Mathematical and Computer Modelling Volume 29, Issue 4, February 1999, Pag...
2005-01-01 | MODEL1006230060 | BioModels
TranscriptomicsMicrorna expression (Agilent McroRNA Array)
MicroRNA profiling of 3 Human NSCLC cell lines (PC9,PC9R,H1975)
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1327 | biostudies-arrayexpress
ProteomicsThe Analysis of Plasma Metabolome and Lipidome of Patients with COVID-19
The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate o...
ORGANISM(S): Homo Sapiens 
PXD018307 |
GenomicsGenome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder in which patients carry premutation alleles of 55-200 CGG repeats on the FMR1 gene. To date, whether alterations in epigenetic regulation modulate FXTAS has gone unexplored. 5-hydroxymethylcytosine (5hmC) ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49463 | biostudies-arrayexpress
ProteomicsJUMPg: an Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080641 | MassIVE
GenomicsEnvironmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in brain and has been impl...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-61194 | biostudies-arrayexpress
TranscriptomicsDownregulation of Myc is essential for terminal erythroid maturation
Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes, followed by chromatin and nuclear condensation and enucleation. The protein levels of c-myc (Myc) are reduced dramatically during late stage erythroid maturation, ...
ORGANISM(S): Mus musculus 
2010-10-13 | E-GEOD-18558 | biostudies-arrayexpress
UnknownA New Method for CTC Images Recognition Based on Machine Learning.
Not available
S-EPMC7423836 | biostudies-literature
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