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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
TranscriptomicsTranscriptome analysis reveals global regulation in response to CO2 supplementation in oleaginous microalga Coccomyxa subellipsoidea C-169
The microalga Coccomyxa subellipsoidea C-169 possesses some features that may be valuable for lipid production, and, as demonstrated in this study, can be greatly induced to produce a high amount of fatty acid by CO2 supplementation. Here we have compared the transcriptome of air group (AG, cells cu...
ORGANISM(S): Coccomyxa subellipsoidea C-169 
2016-05-17 | E-GEOD-76638 | biostudies-arrayexpress
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (L-Alanine-treated macrophage metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7986 | MetaboLights
UnknownStable Gaussian process tracking control of antagonistic variable stiffness actuators.
Not available
S-EPMC12141611 | biostudies-literature
MetabolomicsUntargeted plasma metabolome identifies biomarkers in patients with extracranial arteriovenous malformations

OBJECTIVE: This study aimed to investigate the plasma metabolic profile of patients with extracranial arteriovenous malformations (AVM).

METHOD: Plasma samples were collected from 32 AVM patients and 30 healthy controls (HC). Ultra-high performance liquid c...

2023-10-30 | MTBLS7753 | MetaboLights
ProteomicsSystematic analysis of lysine malonylation in Streptococcus mutans
Lysine malonylation is an evolutionarily conserved PTM from bacteria to mammals and involves malonyl-coenzyme (CoA) as a cofactor. Since the malonyl group has an acidic carboxylic group under physiological pH, malonylated lysine is negatively charged, which might impact on protein function and enzym...
ORGANISM(S): Streptococcus mutans UA159 
2022-11-17 | PXD038045 | Pride
Malonylation Biofilm Post-translational modification Streptococcus mutans 
ProteomicsTUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression
Background: The lack of obvious symptoms of early gastric cancer (GC) as well as the absence of sensitive and specific biomarkers results in poor clinical outcomes. Tubulin is currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040199 | Pride
Lncrna egfr-as1 Tuba1c Gastric cancer Cell cycle 
TranscriptomicsThe MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila
Active genes on the X chromosome of Drosophila males are upregulated by the Male-specific lethal (MSL) complex containing five MSL proteins and two non-coding roX RNAs. To probe the targeting mechanism, we have solved the structure of the MSL3 chromodomain, designed point mutations in key residues t...
ORGANISM(S): Drosophila melanogaster 
2008-11-18 | E-GEOD-11817 | biostudies-arrayexpress
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsAcute depletion of CTCF rewires genome-wide chromatin accessibility
The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute depletion of CTCF globally reduces chromatin interactions but does not s...
ORGANISM(S): Homo sapiens (Human) 
2021-07-04 | PXD026484 | Pride
Multiomics Phosphoproteome Ctcf Proteome 
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