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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsOne Brucella proteins solution sample, complete protein and 5 modifications Label-free omics research (No duplication,F8097WB remaining protein) analysis report.
Considering the role of PTMs(2-hydroxyisobutyrylation, succinylation, crotonylation, acetylation, and malonylation) in various biological processes of Brucella virulence and survival, we propose that the virulence of Brucella is associated with the PTMs of proteins. Taken together, this study provid...
ORGANISM(S): Brucella abortus (strain 2308) 
2022-03-04 | PXD030621 | Pride
Brucella 2308 lc-msms 
TranscriptomicsProfiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas
Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the pre...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23112 | biostudies-arrayexpress
ProteomicsThe mechanism of TRIM21 inhibiting the invasion and migration of ccRCC by stabilizing ASS1
Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive invasion and metastasis, posing significant clinical challenges. Understanding the molecular mechanisms underlying its progression is crucial for developing effective therapeutic strategies. The role of TRIM21 in regulating A...
ORGANISM(S): Homo Sapiens 
2024-08-13 | PXD054847 |
ProteomicsRHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
To further investigate which molecules interact with RHOF in AML，we performed a comparative proteomic analysis of 293T cells overexpressing RHOF and control cells using liquid chromatography‒mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-09 | PXD052126 |
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
2024-10-12 | PXD056753 |
ProteomicsRisk stratification of thyroid papillary cancer based on proteomics and machine learning
Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma accounting for 85%. Most PTCs have a low risk of recurrence and metastasizing and not all low-risk PTCs need immediate surgery. However, cases are often recognized as low-risk only after surgery. Our study aimed to find a pr...
ORGANISM(S): Homo Sapiens 
2024-03-13 | PXD050577 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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