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UnknownEfficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study.
Not available
S-EPMC9985015 | biostudies-literature
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsExpression analysis to identify inducible genes in T cells
Expression microarrays were employed to identify genes induced by phorbol ester and ionomycin stimulation of EL4 cells. EL4 is a murine T cell line. To identify induced genes that were independent of new protein synthesis cells were pre-treated with cycloheximide. This expression study was used in c...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-13278 | biostudies-arrayexpress
UnknownSoluble Klotho Improves Hepatic Glucose and Lipid Homeostasis in Type 2 Diabetes.
Not available
S-EPMC7479259 | biostudies-literature
TranscriptomicsGenome-wide analysis of CD8 cells laser captured from skin biopsies during the mucocutaneous HSV-2 reactivation
Analysis of CD8 cells at the gene expression level during the genital HSV-2 reactivation. We would like to get a comprehensive overview on gene expression of CD8 T-cells during the post healing phases of HSV-2 reactivation. The hypothesis is that CD8 T-cells play a immune surveillance function durin...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-39625 | biostudies-arrayexpress
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
TranscriptomicsThe MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila
Active genes on the X chromosome of Drosophila males are upregulated by the Male-specific lethal (MSL) complex containing five MSL proteins and two non-coding roX RNAs. To probe the targeting mechanism, we have solved the structure of the MSL3 chromodomain, designed point mutations in key residues t...
ORGANISM(S): Drosophila melanogaster 
2008-11-18 | E-GEOD-11817 | biostudies-arrayexpress
ProteomicsActive DNA Demethylation by DNMT3A and DNMT3B - Mechanistic Aspect and In Vivo Evidence
The DNA methylation program is at the bottom layer of the epigenetic regulatory cascade of vertebrate development. While the methylation at C-5 position of the cytosine (C) residues on the vertebrate genomes is achieved through the catalytic activities of the DNA methyltransferases (DNMTs), the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-24 | PXD003401 | Pride
Methylation Lc-msms 
GenomicsTELP, a sensitive and versatile library construction method for next-generation sequencing
Next-generation sequencing has been widely used for the genome-wide profiling of histone modifications, transcription factor binding and gene expression through chromatin immunoprecipitated DNA sequencing (ChIP-seq) and cDNA sequencing (RNA-seq). Here, we describe a versatile library construction me...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-75966 | biostudies-arrayexpress
TranscriptomicsOverlapping and unique responses of E. coli to adverse conditions
In the present study we have determined the global gene expression and biomolecular composition in an Escherichia coli model strain exposed to ten adverse conditions (sodium chloride, ethanol, glycerol, two acids (hydrochloric acid and acetic acid), sodium hydroxide, heat (46°C) and cold (15°C) as...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-05-18 | E-GEOD-11041 | biostudies-arrayexpress
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