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Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
Mycobacterium tuberculosis (M. tb), the cause of tuberculosis (TB), utilizes the blood circulation to spread systemically and establish infection, and the risk of developing active TB (pulmonary and extrapulmonary) is significantly increased in individuals infected with human immunodeficiency virus ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
To identify the potential receptor mediating the effect of Musclin on thermogenic adipocytes, we conducted a proximity-dependent biotin identification (BioID) assay to obtain the interactome of Musclin on the plasma membrane of beige adipocytes.
ORGANISM(S): Mus musculus (Mouse) 
2023-06-13 | PXD041019 | Pride
By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine succinylome analysis was performed. Altogether, 742 lysine succinylation sites in 382 protein groups were identified. Intensive bioinformatic analyses were then carried out to annotate those identifie...
ORGANISM(S): Oryza sativa (Rice) 
2018-10-26 | PXD005582 | Pride
Lysine succinylation has been recognized as a post-translational modification (PTM) in recent years. It is plausible that succinylation may have a vaster functional impact than acetylation due to bulkier structural changes and greater charge differences on the modified lysine residue. Currently, how...
ORGANISM(S): Oryza sativa (Rice) 
2019-09-09 | PXD013664 | Pride
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