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TranscriptomicsmicroRNA and mRNA expression in human hepatitis C Virus liver biopsies
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-15387 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in human hepatitis c virus (HCV) liver biopsy samples
In order to infer the inverse expression relationships between microRNAs and mRNAs during HCV infection, we profiled both microRNA and mRNA expressions in HCV positive (HCV+) and HCV negative (HCV-) human liver biopsy tissue samples. This series includes all microRNA profiles. This series includes m...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-15288 | biostudies-arrayexpress
TranscriptomicsRNA-Seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis
We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression ...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-52405 | biostudies-arrayexpress
TranscriptomicsIntegrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection.
We previously reported widespread differential expression of long non-protein-coding RNAs (ncRNAs) in response to virus infection. Here, we expanded the study through small RNA transcriptome sequencing analysis of the host response to both severe acute respiratory syndrome coronavirus (SARS-CoV) and...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-36971 | biostudies-arrayexpress
TranscriptomicsThe effect of alpha, beta, gamma interferon receptors on host reponse to influenza virus in mouse embryonic fibroblasts
The objective of this study was to examine the host transcriptional response to high and low pathogenecity viruses in mouse embryonic fibroblasts (MEFs) isolated from different mouse genetic backgrounds to further understand the contribution of interferon signaling pathways to host response to influ...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-37665 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of Middle East respiratory syndrome coronavirus (MERS-CoV) in marmosets
The absence of a robust disease model currently hinders the evaluation of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV that results in mild-to-moderate disease has been utilized to describe the pathogenesis of this virus and fo...
ORGANISM(S): Callithrix jacchus 
2014-06-10 | E-GEOD-55023 | biostudies-arrayexpress
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
TranscriptomicsHost cell transcripts during malaria liver stage infection reveals a coordinated and sequential set of biological events
After entering their mammalian host via the bite of an Anopheles mosquito, Plasmodium sporozoites migrate to the liver where they traverse several hepatocytes before invading the one inside which they will develop and multiply into thousands of merozoites. Although this constitutes an essential step...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-14967 | biostudies-arrayexpress
TranscriptomicsRNA-seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis
This dataset includes both whole transcriptome (WT) and mRNA-seq data for interferon-treated mouse samples. This is part of a larger study (GSE52405), where these interferon datasets were used as validation. 6-week-old C57BL/6J mice were treated with 10,000 U of recombinant interferon (Universal Typ...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-55480 | biostudies-arrayexpress
TranscriptomicsDeep transcriptional sequencing of mucosal challenge compartment from rhesus macaques acutely infected with simian immunodeficiency virus implicates loss of cell adhesion preceding immune activation
Recent studies of nonhuman primates (NHPs) have suggested that during the acute phase of infection, antiviral mucosal immunity is restricting viral replication in the primary infection compartment. These studies imply that HIV achieves systemic infection as a consequence of a failure in host antivir...
ORGANISM(S): Macaca mulatta 
2014-04-17 | E-GEOD-56845 | biostudies-arrayexpress
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