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TranscriptomicsToxicogenomic profiling in the whole zebrafish embryo after exposure to reference hepatotoxicants.
Zebrafish embryos have been proposed as an attractive alternative model system for hepatotoxicity testing. In this study we determined gene expression responses after exposure to reference hepatotoxicants and controls to identify biomarkers for hepatotoxicity. 188 samples; hepatotoxic compounds at 3...
ORGANISM(S): Danio rerio 
2014-12-16 | E-GEOD-55618 | biostudies-arrayexpress
TranscriptomicsDose response analysis of monophthalates in the murine embryonic stem cell test
Three embryotoxic phthalate monoesters, monobutyl phthalate (MBuP), monobenzyl phthalate (MBzP) and mono-(2-ethylhexyl) phthalate (MEHP) and the non-embryotoxic monomethyl phthalate (MMP) were studied for their effects on gene expression at several concentrations that did not induce cytotoxicity. 19...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-53969 | biostudies-arrayexpress
TranscriptomicsMolecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.
Murine gene expression responses to Bordetella pertussis were determined in lung and spleen, between 0 and 28 days post infection. Data were compared to other parameters such as microarray, flow cytometry, multiplex immunoassays, and lung clearance. A 57 array study with 27 arrays for lung and 30 fo...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-53294 | biostudies-arrayexpress
TranscriptomicsBiomarkers for Down Syndrome screening in murine fetal liver and placenta
The Ts1Cje mouse strain (Sago, 1998) contains a segmental trisomy of mouse chromosome 16 orthologous to the region of human chromosome 21 commonly associated with Down Syndrome. In this study, fetuses were obtained from wildtype mothers bred with either wildtype or Ts1Cje males. Gene expression prof...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-24272 | biostudies-arrayexpress
TranscriptomicsNeural embryonic stem cell (ESTn) test dose-responses of six compounds.
Effects of six compounds on stem cell neural development.
ORGANISM(S): Mus musculus 
2012-11-08 | E-TABM-1216 | biostudies-arrayexpress
TranscriptomicsNeural embryonic stem cell (ESTn) test dose-responses of Valproic Acid, Cyproconazole and Hexaconazole in the neural embryonic stem cell test.
Effects of Valproic Acid, Cyproconazole and Hexaconazole on stem cell neural development.
ORGANISM(S): Mus musculus 
2012-07-17 | E-TABM-1205 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells treated with developmental toxicants to determine the effects on differentiation
Effects of Developmental Toxicants on Embryonic Stem Cell Differentiation.

There is an additional CDF file (mouse4302daiplusv6.cdf) on the FTP site for this experiment for use with the normalized data file.
ORGANISM(S): Mus musculus 
2010-06-23 | E-TABM-903 | biostudies-arrayexpress
TranscriptomicsBenzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient male mice
DNA damage induced by benzo(a)pyrene may lead to the formation of mutations and as a consequence to the development of diseases. However, it is uncertain whether benzo(a)pyrene causes heritable mutations in male germ cells, which would increase health risks in offspring. In a previous study, benzo(a...
ORGANISM(S): Mus musculus 
2010-08-23 | E-GEOD-17979 | biostudies-arrayexpress
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