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ProteomicsRNA Encoded Peptide Barcodes Enable Efficient in vivo Screening of RNA Delivery Systems
LNPs have been demonstrated to hold great promise for the clinical advancement of RNA therapeutics. Continued exploration of LNPs for application in new disease areas requires identification and optimisation of leads in a high throughput way. Currently available high throughput in vivo screening pla...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD053797 | Pride
Lnp Proteomics Rna In vivo High throughput Barcodes 
ProteomicsPooled scanning of protein variants identifies novel RNA-binding mutants
Binding to RNA has been observed for an ever-increasing number of proteins, which often have other functions. The contributions of RNA binding to protein function are best discerned by studying “separation-of-function” mutants that hamper interaction with RNA without affecting other aspects of prote...
ORGANISM(S): Escherichia coli 
2025-06-20 | PXD062465 | Pride
Lc-ms Protein-rna interactions Technology development Rna-binding proteins Peptide barcodes 
ProteomicsEngineered Peptide Barcodes for Binding Protein Generation
Binding protein generation relies on laborious screening cascades that process candidate molecules individually. To break with this paradigm, we developed NestLink, a binder selection and identification technology able to biophysically characterize thousands of library members at once without handli...
ORGANISM(S): synthetic construct (code 12) 
2019-01-15 | PXD009301 | Pride
Peptide barcode 
GenomicsEngineered Peptide Barcodes for In-Depth Analyses of Binding Protein Ensembles
Engineered Peptide Barcodes for In-Depth Analyses of Binding Protein Ensembles
PRJEB25673 | ENA
UnknownRNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems.
Not available
S-EPMC11381334 | biostudies-literature
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
TranscriptomicsSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of ...
ORGANISM(S): Homo sapiens 
2013-10-16 | E-GEOD-40131 | biostudies-arrayexpress
ProteomicsA proteomic barcoding platform for macromolecular screening and delivery
To address the delivery barriers of macromolecular therapeutics, we sought to develop high-throughput peptide barcoding platform as a homogeneous method for macromolecular screening. Implemented in open-source algorithms, BarcodeBabel and PeptideBabel, this approach permits the design of libraries o...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048412 | Pride
Barcodebabel Barcoding Macromolecular drug delivery Peptidebabel 
UnknownPeptide barcodes in dogs affected by mitral valve disease with and without pulmonary hypertension using MALDI-TOF MS and LC-MS/MS.
Not available
S-EPMC8360550 | biostudies-literature
UnknownOrthogonal coiled coils enable rapid covalent labelling of two distinct membrane proteins with peptide nucleic acid barcodes.
Not available
S-EPMC8341593 | biostudies-literature
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