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ProteomicsPeptide sequences generated by unexpected splicing
Transcripts from the human and mouse CAPN10 cDNA sequences cloned into pcDNA and expressed in cultured cells undergo unexpected splicing. Peptide sequences missing from the spliced version of CAPN10 expressed in COS7 cells were determined by MS analysis.
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2022-01-01 | PXD026551 | JPOST Repository
ProteomicsElucidation of the signatures of proteasome-catalysed peptide splicing
Proteasomes catalyse the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalysed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD021339 | Pride
Protein splicing Proteasome Splicing mechanism 
TranscriptomicsNext generation sequencing reveals gene transcription activities and alternative splicing events in germinating barley embryos
Seed germination triggers a transition of growth and metabolic activities from quiescent to active statuses. Germinating seeds is a good system to study many biological and biochemical processes including hormone metabolic activities and cell wall biosynthesis. Next generation sequence technology is...
ORGANISM(S): Hordeum vulgare subsp. vulgare 
2016-02-18 | E-GEOD-66024 | biostudies-arrayexpress
ProteomicsElucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing
Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalyzed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2021-05-17 | PXD025893 | Pride
Peptide spliicng Proteasome Antigen processing 
TranscriptomicsRNA-seq analysis of alternative splicing events in duplicated genes of Arabidopsis thaliana indicates considerable qualitative and quantitative divergence
Divergence of alternative splicing in duplicated genes is investigated Three replicates of RNA-seq for Arabidopsis first true leaf tissue
ORGANISM(S): Arabidopsis thaliana 
2014-09-30 | E-GEOD-57579 | biostudies-arrayexpress
GenomicsLINC00266-1-encoded peptide regulates mRNA splicing
LINC00266-1-encoded peptide regulates mRNA splicing
PRJNA527803 | ENA
ProteomicsA neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of PKN1
Transactive response DNA-binding protein 43 (TDP-43) is a key factor in maintaining the fidelity of neuronal RNA splicing, and its dysfunction is observed in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) with TDP-43 pathology. Although loss of TDP-43 can activate multiple cryptic ...
ORGANISM(S): Mus Musculus 
PXD069368 |
GenomicsSF3B1 association with chromatin determines splicing outcomes
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. Part of the explanation probably lies in differences in chromatin organization between exons and introns. Pro...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-65644 | biostudies-arrayexpress
ProteomicsIdentification of full length, splicing and cleavage products of SufB protein of SUF-complex of Mycobacterium tuberculosis
SufB, an Fe-S cluster assembly protein is critical for mycobacterial survival and virulence; but as a protein still at its nascent stage. SufB is interrupted by an intein sequence, which excises itself out from the full length protein post-translationally. Intein splicing is crucial for the activati...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis 
2022-02-15 | PXD015199 | Pride
Mycobacterium tuberculosis Sufb Splicing Cleavage products 
TranscriptomicsHP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can act both as an enhancer and as a silencer of splicing, and affects the splicing of more than 20...
ORGANISM(S): Mus musculus 
2015-03-08 | E-GEOD-64910 | biostudies-arrayexpress
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