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MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsThe suberin transporter StABCG1 is required for barrier formation in potato leaves

Suberin is a hydrophobic biopolymer that acts as an internal and external diffusion and transpiration barrier in plants. It is involved in two phases of wound healing, i.e. initial closing layer formation and subsequent wound periderm development. Transcriptomic and metabolomic analyses of wounde...

2024-09-19 | MTBLS4823 | MetaboLights
TranscriptomicsGene expression analysis of a Phaeodactylum tricornutum wild-type strain and a knock-out strain for the Nitrate Transporter 1/Peptide Transporter Family gene PtNPF2
We generated a Phaeodactylum tricornutum strain in which the Nitrate Transporter 1/Peptide Transporter Family gene PtNPF2 was knocked out through the proteolistics CRISPR/Cas9 method. This strain was compared with a wild-type under normal pH conditions and after 24 hours from a shift from pH 8 to pH...
ORGANISM(S): Phaeodactylum tricornutum 
2026-08-28 | E-MTAB-14821 | biostudies-arrayexpress
TranscriptomicsThe antimicrobial peptide-sensing system aps of Staphylococcus aureus
Staphylococcus aureus is a leading cause of hospital-associated infections. In addition, highly virulent strains of methicillin-resistant S. aureus (MRSA) are currently spreading outside health care settings. Survival in the human host is largely defined by the ability of S. aureus to resist mechani...
ORGANISM(S): Staphylococcus aureus 
2008-04-06 | E-GEOD-8400 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
GenomicsGene expression analysis of a Phaeodactylum tricornutum wild-type strain and a knock-out strain for the Nitrate Transporter 1/Peptide Transporter Family gene PtNPF2
Gene expression analysis of a Phaeodactylum tricornutum wild-type strain and a knock-out strain for the Nitrate Transporter 1/Peptide Transporter Family gene PtNPF2
PRJEB85649 | ENA
ProteomicsMass spectrometry analysis of ABC transporter proteins in pilocarpine mouse model of epilepsy
Hippocampal tissue from pilocarpine treated mice was examined by mass spectrometry to determine the change in levels of ABC transporter proteins.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-03 | PXD037454 | Pride
Tmt Pilocarpine Mouse Abc transporter 
TranscriptomicsNorepinephrine transporter-deficient neural crest cells
Background: The goal of this study was to determine the transcriptional consequences of norepinephrine transporter (NET) gene deletion in noradrenergic neuron differentiation. The norepinephrine transporter (NET) is the target of powerful mind-altering substances, such as tricyclic antidepressants a...
ORGANISM(S): Mus musculus 
2008-06-23 | E-GEOD-11788 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and proteomic profiling of human B-LCL cell lines (TAP1/2 +/+ and TAP1/2 -/-) to analyse HLA peptide repertoire
The TAP transporter is responsible for transferring cytosolic peptides into the ER where they can be loaded onto MHC molecules. Deletion of TAP results in a drastic reduction of MHC surface expression and alters the presented peptide pattern. Using the TAP deficient cell line LCL721.174 and its TAP ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9437 | biostudies-arrayexpress
ProteomicsBiosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor
The rice immune receptor XA21 is activated by the sulfated microbial peptide RaxX (required for activation of XA21-mediated immunity X) produced by Xanthomonas oryzae pv. oryzae (Xoo). Mutational studies and targeted proteomics revealed that RaxX is processed and secreted by the protease/transporter...
ORGANISM(S): Xanthomonas Oryzae Pv. Oryzae 
PXD013389 | panorama
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