Peptidoglycan hydrolase

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Unknown (245)
Transcriptomics (106)
Genomics (82)
Proteomics (16)
Other (1)
Metabolomics (1)

Organisms

Caenorhabditis elegans (139)
Alphavirus (8)
Anemia (8)
Archaea (8)
Bacteria (8)
Betaherpesvirinae (8)
Borrelia (8)
Chlamydomonas reinhardtii (8)
Chlorella vulgaris (8)
Clostridium perfringens (8)
Dengue virus (8)
Eukaryota (8)
Staphylococcus aureus (5)
Streptococcus pyogenes (2)
Homo sapiens (2)
Escherichia coli O127:H6 str. E2348/69 (1)
Cereibacter sphaeroides (1)
human oral metagenome (1)
Actinobacillus pleuropneumoniae serovar 1 str. 4074 (1)
Salmonella enterica subsp. enterica (1)
Saccharum officinarum (1)
Escherichia coli O17 str. K12a (1)
Zika virus (1)
Vitis vinifera (1)
Streptomyces venezuelae (1)
Streptococcus pneumoniae (1)
Vibrio cholerae (1)
Drosophila melanogaster (1)
Arabidopsis thaliana (1)
Mus musculus (1)

Organisms

Staphylococcus aureus (3)
Staphylococcus aureus 1101-2 2011 (1)
Staphylococcus aureus 1801-1 2011 (1)
Staphylococcus aureus LysK 2 2011 (1)
Staphylococcus aureus 1801-2 2010 (1)
Staphylococcus aureus 1101-2 2010 (1)
Staphylococcus aureus 1101-1 2010 (1)
Staphylococcus aureus Lyso 2 2010 (1)
Staphylococcus aureus str. Newman 2010 (1)
Staphylococcus aureus 1801-2 2011 (1)
Staphylococcus aureus LysK 1 2011 (1)
Staphylococcus aureus LysK 2 2010 (1)
Staphylococcus aureus 1101-1 2011 (1)
Staphylococcus aureus 1801-1 2010 (1)
Staphylococcus aureus Lyso 1 2010 (1)
Staphylococcus aureus LysK 1 2010 (1)
Staphylococcus warneri Lyso 2 2011 (1)
Staphylococcus warneri Lyso 1 2011 (1)

Repository

biostudies-arrayexpress (162)
ENA (24)
MassIVE (8)
pride (8)
geo (2)
GPMDB (1)
MetaboLights (1)

Tissue

Cell culture (1)
Culture condition:anaerobically-grown cell (1)
Prokaryotic cell (1)
Whole body (1)

Disease

Not Available (1)

Technology Type

Mass Spectrometry (8)
Bottom-up proteomics (3)
Data-dependent acquisition (3)
Top-down proteomics (2)
Mass spectrometry (1)
Gel-based experiment (1)
SWATH MS (1)
Shotgun proteomics (1)

Instrument Platform

NextSeq 500 (4)
NextSeq 550 (2)
Illumina NovaSeq 6000 (2)
Q Exactive HF-X (2)
Illumina HiSeq 3000 (1)
Instrument (1)
LTQ Orbitrap Velos Pro (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion (1)
Orbitrap Fusion Lumos (1)
Q Exactive (1)
Q Exactive Plus (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2010 (61)
2013 (58)
2012 (24)
2025 (9)
2021 (6)
2011 (5)
2022 (3)
2008 (3)
2026 (3)
2014 (2)
2020 (2)
2024 (1)
2023 (1)
2015 (1)
2017 (1)

Metabolite Name

1-Fluoro-25-hydroxy-16-ene-23-yne-26,27-hexadeuterovitamin-D3 (1)
24,24-difluoro-1alpha,25-dihydroxy-24a-homocholecalciferol (1)
1alpha-hydroxy-22-oxacholecalciferol (1)
AC2SGL(18:0/36:0(2Me[S],4Me[S],6Me[S],8Me[S],10Me[S],12Me[R],14Me[R],16Me[R],18Me[R],19OH)) (1)
C25:3 Highly branched isoprenoid A (1)
Hoslundin (1)
PIM2(19:0/16:0) (1)
PA(P-16:0/20:5(5Z,8Z,11Z,14Z,17Z)) (1)
PI(22:2(13Z,16Z)/22:1(11Z)) (1)
PI(20:3(8Z,11Z,14Z)/22:2(13Z,16Z)) (1)
PI(17:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z)) (1)
PG(15:0/22:4(7Z,10Z,13Z,16Z)) (1)
PE-Cer(d16:2(4E,6E)/20:1(11Z)(2OH)) (1)
Isoglobotriglycosylceramide(d18:1/26:0) (1)
PI(20:2(11Z,14Z)/22:1(11Z)) (1)
PA(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (1)
CL(1'-[16:0/16:0],3'-[16:0/16:0]) (1)
CL(1'-[16:0/16:0],3'-[18:1(9Z)/16:0]) (1)
Isoglobotriglycosylceramide(d18:1/24:0) (1)
PI(16:1(9Z)/22:1(11Z)) (1)
1,25-Dihydroxycholesterol (1)
CL(1'-[20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z)],3'-[20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)]) (1)
CL(1'-[16:0/18:0],3'-[18:0/20:0]) (1)
PI(22:4(7Z,10Z,13Z,16Z)/22:1(11Z)) (1)
Isoglobotriglycosylceramide(d18:1/22:0) (1)
Dodecaprenyl phosphate-galacturonic acid (1)
PA(20:4(5Z,8Z,11Z,14Z)/21:0) (1)
MfGL-II (1)
Capilliposide I (1)
Syriacin (1)

First Public Date

2014 (19)
2023 (2)
2021 (1)
2020 (1)
2017 (1)

Classification

bacteria (18)

Study type

ChIP-chip by tiling array (83)
ChIP-seq (58)
Transcription profiling by array (11)
RNA-seq of coding RNA (5)
Comparative genomic hybridization by array (2)
Cell line - High-throughput sequencing (1)
RNA-seq of coding RNA from single cells (1)
RNA-seq of total RNA (1)

Release Date

2013 (69)
2010 (66)
2012 (35)
2025 (27)
2022 (27)
2023 (21)
2020 (17)
2016 (17)
2024 (16)
2017 (16)
2021 (15)
2019 (14)
2014 (12)
2011 (9)
2015 (8)
2018 (8)
2008 (5)
2006 (5)
2009 (4)
2026 (3)
2001 (3)
2004 (2)
2003 (2)
2000 (2)
2007 (1)
2005 (1)
2002 (1)
1998 (1)

Lab affiliation

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil (1)
Department of Immunology & Microbiology, Scripps Research, USA (1)
Department of Microbial Proteomics, University of Greifswald, Centre of Functional Genomics of Microbes, Institute of Microbiology, Greifswald, Germany (1)
Institut Pasteur, Université Paris Cité, Unit Evolutionary Biology of Microbial Cell, Paris, France (1)
Institut für Experimentelle Medizin (IEM) Arbeitsgruppe Systematische Proteomforschung Christian-Albrechts-Universität zu Kiel Kiel, Germany (1)
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa; Oeiras, Portugal. (1)
Laboratoire Pathogénese des Bactéries Anaérobies, Institut Pasteur, UMR CNRS 2001, Université de Paris, Paris, France (1)
MRC Laboratory of Medical Sciences (LMS) (1)

Tags

pathogen (18)
pathogen:bacterium (18)

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Archaea produce peptidoglycan hydrolases that kill bacteria

The social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically ta...

ORGANISM(S): Haloferax volcanii SB1

2026-02-07 | PXD064732 | Pride

Archaea Peptidoglycan hydrolase

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infections globally and demands new approaches for treatment. Here we show that genetic and pharmacological inactivation of a highly conserved NlpC/P60 peptidoglycan hydrolase, secreted antigen A (SagA), en...

ORGANISM(S): Enterococcus faecium ERV165

2026-04-13 | PXD075040 | Pride

Antibiotic adjuvant Covalent inhibitor Chemoproteomics Vancomycin-resistant enterococcus faecium Peptidoglycan hydrolase

The Serine/Threonine kinase PrkC of Clostridioides difficile regulates export of CD1135, a septal peptidoglycan hydrolase

Cell growth and division require a balance between synthesis and hydrolysis of the peptidoglycan (PG). Inhibition of PG synthesis or uncontrolled PG hydrolysis can be lethal for the cells, making it imperative to control peptidoglycan hydrolase (PGH) activity. The activity of several enzymes involv...

ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile)

2021-04-08 | PXD021541 | Pride

Phosphoproteomics Clostridium difficile Qexactive plus Phostag

Two-step localization driven by peptidoglycan hydrolase in interbacterial predation.

Not available

S-EPMC12510463 | biostudies-literature

Staphylococcus aureus 1101-2 2011

Identification of genomic changes in Staphylococcus aureus that confer resistance to peptidoglycan hydrolase antimicrobial enzymes

PRJNA235872 | ENA

Staphylococcus aureus str. Newman 2010

Identification of genomic changes in Staphylococcus aureus that confer resistance to peptidoglycan hydrolase antimicrobial enzymes

PRJNA235858 | ENA