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TranscriptomicsGene Expression Profile of AGS cell line cultured in 2D and in 3D conditions
AGS cell line was cultured in standard T25 flasks (2D condition) and in T25 flasks precoated with 50 M-5L/cm2 of matrigel basement membrane (BD Biosciences) at a 1.5:1 proportion to RPMI serum-free medium (3D condition, overlay method). Cultures were maintained for 14 days with medium change every t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1234 | biostudies-arrayexpress
UnknownWorldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.

Background

Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to ...
S-EPMC5735219 | biostudies-literature
UnknownWorldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.

Background

Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 2...
S-EPMC7615769 | biostudies-literature
UnknownDiminishing benefits of urban living for children and adolescents' growth and development.
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1-6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of child...
S-EPMC10060164 | biostudies-literature
UnknownHeight and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.

Background

Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-a...
S-EPMC7658740 | biostudies-literature
UnknownClinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.

Objectives

To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population.

Methods

This retrospective cohort included consecutive adult pati...
S-EPMC9941311 | biostudies-literature
UnknownAssessment of the ABC2-SPH risk score to predict invasive mechanical ventilation in COVID-19 patients and comparison to other scores.

Background

Predicting the need for invasive mechanical ventilation (IMV) is important for the allocation of human and technological resources, improvement of surveillance, and use of effective therapeutic measures. This study aimed (i) to assess whether the ABC2-SPH score is able ...
S-EPMC10690599 | biostudies-literature
UnknownHydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.

Background

Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

Methods

We conducted a multicenter, randomized, open-label, three-group, controlled tri...
S-EPMC7397242 | biostudies-literature
UnknownCOVID-19 outcomes in people living with HIV: Peering through the waves.

Objective

To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection.

Methods

This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained th...
S-EPMC10209448 | biostudies-literature
UnknownDevelopment and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients.

Background

Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting the need for KRT in hospitalised COVID-19 patients, and...
S-EPMC9438299 | biostudies-literature
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