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TranscriptomicsGene expression changes in PBMCs from metabolic syndrome patients after acute intake of phenol-rich virgin olive oil
Some studies have shown that acute intake of high-phenol virgin olive oil reduces pro-inflammatory, pro-oxidant and pro-thrombotic states, but nowadays still remains unclear if those effects attributed to its phenolic fraction could be exerted at transcriptional level in vivo. Two virgin olive oil-b...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15812 | biostudies-arrayexpress
UnknownIdentification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.
The endogenous protease furin is a key protein in many different diseases, such as cancer and infections. For this reason, a wide range of studies has focused on targeting furin from a therapeutic point of view. Our main objective consisted of identifying new compounds that could enlarge the furin i...
S-EPMC8911046 | biostudies-literature
UnknownMultifunctional Peptides from Spanish Dry-Cured Pork Ham: Endothelial Responses and Molecular Modeling Studies.
Food peptides contain a very wide range of diversified structures, which explains their diverse range of functional activities. Proatherogenic endothelium is related to vasoconstriction, inflammation, and oxidative stress. In this line, four synthetic bioactive peptides from dry-cured pork ham, prev...
S-EPMC6747274 | biostudies-literature
ModelsLeon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia
This model is based on the publication: "CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models". Odelaisy León-Triana, Soukaina Sabir, Gabriel F. Calvo, Juan Belmonte-Beitia, Salvador Chulián, Álvaro Martínez-Rubio, María Rosa, Antonio Pérez-Martínez, Manuel R...
2024-09-02 | BIOMD0000001011 | BioModels
Immuno-oncology 
ModelsLeon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia with contribution from immature B cells
This model is based on the publication: "CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models". Odelaisy León-Triana, Soukaina Sabir, Gabriel F. Calvo, Juan Belmonte-Beitia, Salvador Chulián, Álvaro Martínez-Rubio, María Rosa, Antonio Pérez-Martínez, Manuel R...
2024-09-02 | BIOMD0000001012 | BioModels
Immuno-oncology 
UnknownIdentification of new allosteric sites and modulators of AChE through computational and experimental tools.
Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for am...
S-EPMC6010107 | biostudies-literature
UnknownCurrent Trends of Bacterial and Fungal Optoproteins for Novel Optical Applications.
Photoproteins, luminescent proteins or optoproteins are a kind of light-response protein responsible for the conversion of light into biochemical energy that is used by some bacteria or fungi to regulate specific biological processes. Within these specific proteins, there are groups such as the phot...
S-EPMC10572898 | biostudies-literature
UnknownStudying SARS-CoV-2 interactions using phage-displayed receptor binding domain as a model protein.
SARS-CoV-2 receptor binding domain (RBD) mediates viral entry into human cells through its interaction with angiotensin converting enzyme 2 (ACE2). Most neutralizing antibodies elicited by infection or vaccination target this domain. Such a functional relevance, together with large RBD sequence vari...
S-EPMC10771503 | biostudies-literature
UnknownPsychosocial changes during COVID-19 lockdown on nursing home residents, their relatives and clinical staff: a prospective observational study.

Background

Previous works have observed an increase of depression and other psychological disorders on nursing home residents as a consequence of coronavirus disease 2019 (COVID-19) lockdown; however, there are few studies that have performed a comprehensive evaluation of all people involved...
S-EPMC9897885 | biostudies-literature
UnknownThree Varieties of Grape Pomace, with Distinctive Extractable:Non-Extractable Polyphenol Ratios, Differentially Reduce Obesity and Its Complications in Rats Fed a High-Fat High-Fructose Diet.
Grape pomace is a commonly discarded by-product characterized by high extractable (EPP) and non-extractable (NEPP) polyphenol contents which exhibits anti-obesogenic effects. However, the relevance of each fraction needs to be elucidated. In this work, we examined the effects of three pomaces with d...
S-EPMC10093191 | biostudies-literature
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