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ProteomicsA carrier-based quantitative proteomics method applied to biomarker discovery in pericardial fluid
Data-dependent liquid chromatography tandem mass spectrometry (LC-MS/MS) is challenged by the large concentration range of proteins in plasma and related fluids. We adapted the SCoPE method from single-cell proteomics to pericardial fluid, where a myocardial tissue carrier was used to aid protein qu...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD053450 | Pride
Carrier proteome Single-cell proteomics Biomarker discovery 
ProteomicsPericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling
Patients with aortic stenosis are often indicated to aortic valve replacement to relief pressure overload. After surgery, patients experience a myocardial response commonly known as reverse remodeling, where structural and functional recovery are expected. Notwithstanding, some patients exhibit an i...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD015607 | Pride
Human Coronary artery disease Aortic stenosis Pericardial fluid Reverse remodeling 
ProteomicsCharacterization of pericardial fluid proteome through fractionation with magnetic nanoparticles (NPs@EDTA)
Despite the invasive nature of its collection, being in close contact to the heart, the pericardial fluid (PF) proteome reflects the pathophysiological status of this organ. Therefore, whenever it is available, e.g. on occasion of open-heart surgery, PF proteomic analysis can give important clues of...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD008620 | Pride
Human Magnetic nanoparticles Pericardial fluid Fractionation 
GenomicsPericardial fluid exosome miRNA profiling
Pericardial fluid exosome miRNA profiling
PRJNA484411 | ENA
ProteomicsProteomics analysis of human pericardial fluid
Pericardial fluid (PF) is considered as biochemical window of heart. Knowledge of the entire protein content, the proteome of human PF, would give insights into heart and cardiovascular diseases. To date, there have been limited attempt to perform an in-depth analysis of the PF proteome. In this stu...
ORGANISM(S): Homo sapiens (Human) 
2013-07-09 | PXD000194 | Pride
Pericardial fluid Heart Proteomics Cardiovascular diseases Biomarkers 
GenomicsPericardial fluid microRNAs in patients with arrhythmogenic right ventricular cardiomyopathy or ischemic heart disease
Pericardial fluid microRNAs in patients with arrhythmogenic right ventricular cardiomyopathy or ischemic heart disease
PRJNA690937 | ENA
GenomicsCharacteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients
Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients
PRJNA485430 | ENA
TranscriptomicsPericardial fluid exosome miRNA profiling
Pericardial sac surrounding the heart contains pericardial fluid (PF), which is rich in exosomes. PF exosomes increase angiogenesis in hypoxic endothelial cells and in animal model of hindlimb ischemia by passing the proangiogenic miRNAs to recipient cells. However, under pathological conditions suc...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE118103 | GEO
GenomicsPericardial fluid microRNAs in patients with arrhythmogenic right ventricular cardiomyopathy or ischemic heart disease
Pericardial fluid is enriched by biologically active molecules of cardiovascular origin including microRNAs. Investigation of the disease-specific extracellular microRNAs could shed light on the molecular processes underlying disease development. Arrhythmogenic right ventricular cardiomyopathy (ARVC...
ORGANISM(S): Homo sapiens 
2021-03-09 | GSE164490 | GEO
GenomicsPericardial Fluid of Patients with Coronary Artery Disease Can Drive Fibrosis via TGF-Beta Signalling Pathway
Pericardial Fluid of Patients with Coronary Artery Disease Can Drive Fibrosis via TGF-Beta Signalling Pathway
PRJNA1090494 | ENA
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