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GenomicsSpecificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts
We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that expla...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-58555 | biostudies-arrayexpress
Genomicsproj022_chipseq
The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation ...
ORGANISM(S): Mus musculus 
2014-05-23 | E-MTAB-2481 | biostudies-arrayexpress
TranscriptomicsSpt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe
Spt6 is a conserved factor, critically required for several transcription and chromatin related processes. We now show that Spt6 and its binding partner, Iws1, are required for heterochromatic silencing in Schizosaccharomyces pombe. Our studies demonstrate that Spt6 is required for silencing of al...
ORGANISM(S): Schizosaccharomyces pombe 
2011-10-20 | E-MTAB-738 | biostudies-arrayexpress
TranscriptomicsRelics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa
Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa sports features of heterochromatin found in higher eu...
ORGANISM(S): Neurospora crassa 
2010-05-15 | E-GEOD-12690 | biostudies-arrayexpress
GenomicsSilencing of pericentric heterochromatin associated with SIRT6-dependent H3K18 deacetylation protects against mitotic errors and cellular senescence
Pericentric heterochromatin silencing at mammalian centromeres is essential for mitotic fidelity and genomic stability. Defective pericentric silencing is observed in senescent cells, aging tissues, and mammalian tumors, but the underlying mechanisms and functional consequences of these defects are ...
ORGANISM(S): Homo sapiens 
2016-04-04 | E-GEOD-69809 | biostudies-arrayexpress
TranscriptomicsNuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly
RNAseIII ribonucleases act at the heart of RNA silencing pathways by processing precursor RNAs into mature microRNAs and siRNAs. In the fission yeast Schizosaccharomyces pombe, siRNAs are generated by the RNAseIII enzyme Dcr1 and are required for heterochromatin formation. In this study, we have ana...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-16 | E-GEOD-18582 | biostudies-arrayexpress
GenomicsA transcription factor based mechanism for mouse heterochromatin formation
We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is ...
ORGANISM(S): Mus musculus 
2012-09-16 | E-GEOD-40086 | biostudies-arrayexpress
TranscriptomicsArgonaute Surveillance and Dicer-Independent priRNAs TriggerRNAi and Heterochromatin Formation
The assembly of fission yeast pericentromeric heterochromatin and generation of small interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent processes. How this interdependent positive feedback loop is first triggered is a fundamental unanswered question. Here we sho...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-23 | E-GEOD-19734 | biostudies-arrayexpress
TranscriptomicsMolecular landscape of modified histones in Drosophila heterochromatin
The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Since heterochromatin is repeat-rich, strin...
ORGANISM(S): Drosophila melanogaster 
2010-06-29 | E-GEOD-7839 | biostudies-arrayexpress
ProteomicsMBD2 modulates heterochromatin architecture and composition
Heterochromatin (HC) is essential for nuclear integrity, genome stability, and gene regulation with pericentric heterochromatin (PCH) playing a key role. However, the mechanisms governing PCH compartmentalization remain poorly understood. Recent studies suggest that phase separation (PS) underlies t...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD055626 | Pride
Mice brain Dia-ms Mbd2 Pericentric heterochromatin Alphafold server Nuclear fractionation Ps prediction tools Phase separation 
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