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GenomicsGenome wide profiling of MBD2 binding
We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. We also report that MBD2 binds to a subset of CpG island promoters that are characterized by the presence of active histone marks and RNA polymerase II (Pol2). At such sites, MBD2 binds downstream of th...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54693 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells after MBD2 and MBD3 knock down
The heterogeneous collection of NuRD complexes can be grouped into the MBD2 or MBD3 containing complexes MBD2-NuRD and MBD3-NuRD. MBD2 is known to bind to methylated CpG sequences in vitro in contrast to MBD3. Although functional differences have been described, a direct comparison of MBD2 and MBD3 ...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41003 | biostudies-arrayexpress
GenomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (1)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63233 | biostudies-arrayexpress
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (3)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63235 | biostudies-arrayexpress
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (2)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63234 | biostudies-arrayexpress
GenomicsGenome-wide identification of MBD2 and MBD3 binding sites by ChIP-seq
The heterogeneous collection of NuRD complexes can be grouped into the MBD2 or MBD3 containing complexes MBD2-NuRD and MBD3-NuRD. Although functional differences have been described, a direct comparison of MBD2 and MBD3 in respect to genome-wide binding and function has been lacking. Here we show a ...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41006 | biostudies-arrayexpress
ProteomicsMBD2 modulates heterochromatin architecture and composition
Heterochromatin (HC) is essential for nuclear integrity, genome stability, and gene regulation with pericentric heterochromatin (PCH) playing a key role. However, the mechanisms governing PCH compartmentalization remain poorly understood. Recent studies suggest that phase separation (PS) underlies t...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD055626 | Pride
Mice brain Dia-ms Mbd2 Pericentric heterochromatin Alphafold server Nuclear fractionation Ps prediction tools Phase separation 
GenomicsDifferential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and exon sequences
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41010 | biostudies-arrayexpress
TranscriptomicsRNAi - MBD2 - MRC5 cells
Relationship between MBD2 depletion and gene expression in a normal human fibroblastic cell line, MRC5
ORGANISM(S): Homo sapiens 
2011-09-16 | E-MEXP-2916 | biostudies-arrayexpress
TranscriptomicsMethyl-CpG-Binding Protein MBD2 plays a critical role in maintenance and spread of DNA methylation of CpG islands and shores in cancer (expression)
Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-associated promoters, including tumour suppressor genes The methyl-CpG-binding domain (MBD) family of proteins bind to methylated DNA and can aid in the meditation of gene silencing by interaction with histone deacetyla...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-77187 | biostudies-arrayexpress
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