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TranscriptomicsTranscriptomic Analysis of PNN- and ESRP1-regulation in Human Corneal Epithelial Cells
Pnn depletion in developing mouse corneal epithelium led to disrupted alternative splicing of multiple ESRP-regulated epithelial-type exons. In human corneal epithelial cells (HCET), ESRP1 and PNN displayed close localization in and around nuclear speckles and their physical association in protein c...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-41996 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells
The specialized corneal epithelium requires differentiated properties, specific for its role at the anterior surface of the eye, thus tight maintenance of the differentiated qualities of the corneal epithelial is essential. Our studies have focused on pinin (PNN), an exon junction component (EJC) t...
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-73060 | biostudies-arrayexpress
GenomicsAstrocytic Regulation of aberrant perineuronal net formation in Mecp2-null Neocortex
Astrocytic Regulation of aberrant perineuronal net formation in Mecp2-null Neocortex
PRJNA1311580 | ENA
TranscriptomicsAstrocytic Regulation of aberrant perineuronal net formation in Mecp2-null Neocortex
Rett syndrome (RTT), caused by mutations in MECP2, is a complex neurological disorder characterized by myriad physiological disruptions, including early closure of the critical period of developmental plasticity and precocious formation of perineuronal nets (PNNs). PNNs are lattice-like substructure...
ORGANISM(S): Mus musculus 
2026-06-30 | GSE306651 | GEO
UnknownEffect of Shock-Induced Cavitation Bubble Collapse on the damage in the Simulated Perineuronal Net of the Brain.
Not available
S-EPMC5509702 | biostudies-literature
UnknownCortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
Not available
S-EPMC4356748 | biostudies-literature
UnknownPerineuronal net deglycosylation associates with tauopathy-induced gliosis and neurodegeneration.
Not available
S-EPMC11298576 | biostudies-literature
UnknownNeonatal Zika virus infection causes transient perineuronal net degradation.
Not available
S-EPMC10366369 | biostudies-literature
UnknownHippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets.
Not available
S-EPMC12007587 | biostudies-literature
UnknownEffects of adolescent intermittent ethanol exposure on cortical perineuronal net and parvalbumin expression in adulthood mediate behavioral inflexibility.
Not available
S-EPMC11305908 | biostudies-literature
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