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MetabolomicsPeroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001202 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial treatment timecourse on trophozoite-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001201 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial extended treatment timecourse on trophozoite-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001204 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001205 | MetabolomicsWorkbench
ProteomicsPeroxide antimalarial drugs impact redox homeostasis in Plasmodium falciparum infected red blood cells
Plasmodium falciparum causes the most lethal form of malaria. The frontline treatments for this severe disease are combination therapies based on semisynthetic peroxide antimalarials, known as artemisinins. There is growing resistance to artemisinins and new drugs with novel mechanisms of action are...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2022-02-17 | PXD027334 | Pride
Plasmodium falciparum Malaria Redox homeostasis Peroxides Glutathione. Ozonides 
UnknownSynthesis and Study of the Antimalarial Cardamom Peroxide.
Not available
S-EPMC6181145 | biostudies-literature
UnknownFour-step synthesis of the antimalarial cardamom peroxide via an oxygen stitching strategy.
Not available
S-EPMC4353017 | biostudies-literature
ProteomicsComparison of the proteome-wide alkylation signatures of antimalarial peroxides: ozonides vs. artemisinin
Antimalarial peroxides such as the phytochemical artemisinin or the synthetic artefenomel are activated by reductive cleavage of the peroxide bond. This happens inside the malaria parasite, presumably in the food vacuole with ferrous heme as the electron donor. The generated carbon-centered radicals...
ORGANISM(S): Plasmodium falciparum NF135/5.C10 
2022-02-24 | PXD010264 | Pride
Malaria Label-free quantification Peroxides 
ProteomicsSystem-wide biochemical analysis reveals ozonide and artemisinin antimalarials initially act by disrupting malaria parasite haemoglobin digestion
Artemisinins are currently the first-line antimalarials, and rely on a peroxide pharmacophore for their potent activity. OZ277 (arterolane) and OZ439 (artefenomel) are newer synthetic peroxide-based antimalarials with potent activity against the deadliest malaria parasite, Plasmodium falciparum. Her...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2020-05-25 | PXD014313 | Pride
Metabolomics Peptidomics Peroxide antimalarial Malaria Proteomics Plasmodium falciparum 
UnknownPeroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells.
Not available
S-EPMC8762662 | biostudies-literature
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