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ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, secretome analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028772 | Pride
Secretome analysis Peroxiredoxin 6 Cellular senescence Dia Exploris Ionizing radiation 
MetabolomicsExploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a hydroxamic a...

2026-06-23 | MTBLS14782 | MetaboLights
ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, redox proteomic analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028780 | Pride
Peroxiredoxin 6 Cellular senescence Silac-iodotmt Ionizing radiation Redox proteomics 
MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
TranscriptomicsRNA-Seq of human skeletal muscle cell line AB1167, with groups of PRDX2 KD, treated with electrical stimulation and both 2.5 and 5uM H202 for 15 minutes
This study investigates the role of peroxiredoxin 2 (PRDX2) in mediating oxidative adaptations in human skeletal muscle myotubes subjected to mechanical contraction and hydrogen peroxide (H2O2) exposure. additionally, the effect of an electrical stimulation protocol was assessed pre and post PRDX2 K...
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14577 | biostudies-arrayexpress
ProteomicsProteomics of post-mortem beef tenderization: The role of oxidative stress and peroxiredoxin 6 (Prdx6)
This study explored the role of peroxiredoxin 6 (Prdx6) non-selenium glutathione peroxidase (NSGPx) activity on the regulation of beef tenderization during post-mortem aging periods of up to 168 h. Shear force, NSGPx activity, differential protein expression, heat shock protein 70 (HSP70), heat shoc...
ORGANISM(S): Bos Taurus 
2025-01-28 | PXD060488 |
ProteomicsGlobal proteomics of Peroxiredoxin 6 knockdown A549 cells subjected to ionizing radiation
In this project, we have performed global proteomics of A549 lung cancer cells subjected to Peroxiredoxin 6 knockdown, 4Gy ionizing or combination of both. The aim of the project is to find out proteome level alterations in PRDX6KD cell which make them sensitive to ionizing radiation mediated cell d...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD076585 | Pride
Ferroptosis A549 Nsclc Peroxiredoxin Radiation. 
TranscriptomicsComparison of bone marrow-derived macrophages from BALB/c and C57BL/6 mice with and without interferon-gamma stimulation.
ABSTRACT Macrophages are essential components of the innate immune system and crucial for pathogen elimination in early stages of infection. We previously observed that bone marrow-derived macrophages (BMM) from C57BL/6 mice exhibited increased killing activity against Burkholderia pseudomallei comp...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-39349 | biostudies-arrayexpress
ProteomicsProteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and enhanced cysteine metabolic pathways
Equine myofibrillar myopathy (MFM) causes exertional muscle pain and is characterized by myofibrillar disarray and ectopic protein aggregates of unknown origin. To investigate the pathophysiology of MFM, we compared the skeletal muscle proteome and 3 h post-exercise transcriptome of gluteal muscle i...
ORGANISM(S): Equus caballus (Horse) 
2019-11-12 | PXD009362 | Pride
Myopathy Horse Antioxidant Proteome 
UnknownPeroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis.
Not available
S-EPMC1698852 | biostudies-literature
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