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ProteomicsHeterooligomerisation is a conserved feature of eukaryotic typical 2-Cys peroxiredoxins
Peroxiredoxins are conserved thiol peroxidases for peroxide detoxification, redox signaling, and chaperone activity. Peroxiredoxin 1-type typical 2-Cys peroxiredoxins are present in both prokaryotes and eukaryotes, with multiple closely related isoforms often coexisting within the same subcellular c...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-03-11 | PXD060819 | Pride
Heterooligomers Eukaryotes Redox homeostasis Peroxiredoxins 
ProteomicsThe Human 2-Cys Peroxiredoxins Form Widespread, Cysteine-Dependent- And Isoform-Specific Protein-Protein Interactions.
Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger. However, H2O2 reacts poorly with most cysteine thiols and it is not clear how it discriminates between cysteines to trigger appropriate sign...
ORGANISM(S): Homo sapiens (Human) 
2021-05-04 | PXD024114 | Pride
Protein thiol oxidation Cysteine sulfenic acid Hydrogen peroxide Thiol disulfide exchange Peroxiredoxin  redox signaling  redox relay 
ProteomicsIdentification of A. thaliana 2-Cys peroxiredoxins interacting proteins
Peroxiredoxins are ubiquitous thiol-dependent peroxidases for which chaperone and signaling roles have been reported in various types of organisms in the last years. In plants, the peroxidase function of the two typical plastidial 2-Cys peroxiredoxins (2-Cys PRX A and B) has been highlighted while t...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-10-11 | PXD003923 | Pride
A. thaliana Peroxiredoxins Nanolc-ms/ms Interactome 
UnknownPeroxiredoxins in Cancer and Response to Radiation Therapies.
Not available
S-EPMC6356878 | biostudies-literature
UnknownTypical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Not available
S-EPMC2747500 | biostudies-literature
UnknownPiecing Together How Peroxiredoxins Maintain Genomic Stability.
Not available
S-EPMC6316004 | biostudies-literature
UnknownA role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation.
Not available
S-EPMC5863949 | biostudies-literature
UnknownDistribution and Features of the Six Classes of Peroxiredoxins.
Not available
S-EPMC4749874 | biostudies-literature
UnknownDimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.
Not available
S-EPMC4811492 | biostudies-literature
ProteomicsRedox proteomic analysis of H2O2 -treated Jurkat cells and effects of bicarbonate and peroxiredoxins 1 and 2
Oxidation of thiol proteins and redox signaling occur in cells exposed to H2O2 but mechanisms are unclear. We used redox proteomics to seek evidence of oxidation of specific proteins either by a mechanism involving reaction of H2O2 with CO2/bicarbonate to give the more reactive peroxymonocarbonate...
ORGANISM(S): Homo Sapiens 
2024-07-08 | PXD053738 |
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