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ProteomicsGenetic determinants of genomic stability identified by comprehensive in vivo analyses of micronucleus formation
Genomic instability arising from defective DNA damage response or mitotic chromosomal imbalance can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and genomic instability-associated diseases, the catalogue of genetic...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD045110 | Pride
Genomic stability Micronucleus formation 
ProteomicsGenetic determinants of genomic stability identified by comprehensive in vivo analyses of micronucleus formation
Genomic instability due to defective DNA damage response or arising from mitotic chromosomal imbalance can lead to sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of genomic instability associated diseases and ageing, the catalogue of gen...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD030499 | Pride
Ms3 Human Tmt 
ProteomicsProteomic analysis of Dscc1 knockout mouse cells
In this project we aimed to explore the effect of Dscc1 gene loss on the proteome. Embyros from wildtype and aged matched Dssc1 null embryos were profiled.
ORGANISM(S): Mus musculus (Mouse) 
2023-11-17 | PXD034902 | Pride
Knock out Ms/ms Dscc1 Mouse 
UnknownDamaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.
Not available
S-EPMC11496107 | biostudies-literature
UnknownThe NEMP family supports metazoan fertility and nuclear envelope stiffness.
Not available
S-EPMC7455189 | biostudies-literature
UnknownIdentification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
Not available
S-EPMC4863559 | biostudies-literature
UnknownAssociation Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.
Not available
S-EPMC5386134 | biostudies-literature
UnknownPopulation analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection.
Not available
S-EPMC9915812 | biostudies-literature
GenomicsGoT2D: Genetics of Type 2 Diabetes, a study of the the genetic architecture of type 2 diabetes using low pass whole genome sequencing and high density SNP genotyping in 2,657 individuals.
The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
EGAS00001001459 | EGA
UnknownCorrection: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
Not available
S-EPMC6894746 | biostudies-literature
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