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TranscriptomicsHIF orchestrated metabolic shift confers protection against Acute Kidney Injury (AKI)
Renal hypoxia is widespread in acute kidney injury (AKI) of various aetiologies. Hypoxia adaptation, conferred through the hypoxia-inducible factor (HIF), appears to be insufficient. Here we show that HIF activation in renal tubules through Pax8-rtTA-based inducible knockout of von Hippel-Lindau pro...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-44925 | biostudies-arrayexpress
ProteomicsA renal function for 2,3-bisphosphoglycerate mutase (BPGM)
The enzyme 2,3 bisphosphoglycerate mutase (BPGM) catalyzes the production of 2,3-bisphosphoglycerate (2,3-BPG). The main role of 2,3-BPG is to shift the equilibrium of hemoglobin toward the deoxy-state, accounting for the notion that 2,3-BPG production would appear to be solely useful in cells which...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD033095 | Pride
Metabolism Nephron Reactive oxygen species (ros) Kidney Bpgm Acute kidney injury (aki) Apoptosis 
TranscriptomicsTranscriptome partitioning for mRNA translation in hypoxia
Protein synthesis belongs to the most energy consuming processes in the cell. Lowering oxygen tension below normal (hypoxia) causes a rapid inhibition of global mRNA translation due to the decreased availability of energy. Interestingly, subsets of mRNAs pursue active translation under such circumst...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-49029 | biostudies-arrayexpress
UnknownCopper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model.
Not available
S-EPMC12188662 | biostudies-literature
ProteomicsA renal function for 2,3-bisphosphoglycerate mutase (BPGM)
The enzyme 2,3 bisphosphoglycerate mutase (BPGM) catalyzes the production of 2,3-bisphosphoglycerate (2,3-BPG). The main role of 2,3-BPG is to shift the equilibrium of hemoglobin toward the deoxy-state, accounting for the notion that 2,3-BPG production would appear to be solely useful in cells which...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040789 | Pride
Metabolism Nephron Reactive oxygen species (ros) Kidney Bpgm Acute kidney injury (aki) Apoptosis 
TranscriptomicsTranscriptome analysis of medulloblastoma tumors in mice
The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally-stabilized murine N-mycT58A into neural stem cells (NSCs) from perinatal murine cerebellum, brain s...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-36594 | biostudies-arrayexpress
UnknownPI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
Not available
S-EPMC10940093 | biostudies-literature
UnknownHelicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease.
Not available
S-EPMC10245814 | biostudies-literature
UnknownEvidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium.
Not available
S-EPMC12481164 | biostudies-literature
UnknownRivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.
Not available
S-EPMC11198259 | biostudies-literature
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